Red palms and soles can be due cold extremities, as seen in hypothyroidism, eating disorders like anorexia, Vit B12 deficiency, Addison’s disease, adrenal causes like pheochromocytoma,
anemia, Buerger’s disease, chronic fatigue syndrome
and Raynaud’s disease. You will need some tests like treadmill test, color Doppler, angiography, ultrasonography and MRI (magnetic resonance imaging). Drugs like beta blockers which are used as antihypertensives can also cause cold extremities.