Acyclovir bioavailability

Common Questions and Answers about Acyclovir bioavailability

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Avatar n tn In a multiple-dose cross-over study where 23 volunteers received acyclovir as one 200mg capsule, one 400mg tablet and one 800mg tablet 6 times daily, absorption decreased with increasing dose and the estimated bioavailabilities of acyclovir were 20%, 15% and 10% respectively. The decrease in bioavailability is believed to be a function of the dose and not the dosage form. It was demonstrated that acyclovir is not dose proportional over the dosing range 200mg to 800mg.
Avatar f tn postmarketing experience with valacyclovir provides evidence of favorable safety and efficacy in herpes simplex virus (HSV) management. Valacyclovir enhances acyclovir bioavailability compared with orally administered acyclovir. Long-term use of acyclovir for up to 10 years for HSV suppression is effective and well tolerated.
Avatar n tn Atorvastatin is supposed to be one of the two most effective statins in lowing cholesterol so you are on a good one. Bioavailability is how well a med is absorbed and used by the body and bioavailability varies among the statins. It's actually a desired thing. The liver is the target organ so if it is slowed down in the liver (where this happens), it's in the target organ. But honestly, that is hard for me to understand.
Avatar m tn You are confused. There is a valine ester hanging off of the acyclovir formulation that makes valacyclovir (Valtrex) able to have better bioavailability. That is NOT the active ingredient. There are no supplements that have been shown to be effective in dealing with herpes, unfortunately. I'm not clear that anyone is closest to a cure. There are certainly interesting research being done at several sites including University of Washington, Illinois, and Florida.
Avatar m tn Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h. The type of meal also influenced the first-order input part of the absorption model (Table 1).
Avatar f tn I stopped taking acyclovir in December 2011. I have had numerous outbreaks like once a month or every couple of months. I have had HSV2 four years and four months now. My last outbreak was maybe eight weeks ago. Shouldn't my outbreaks decrease since I have had the virus for some time.I would like to know is that too many outbreaks to be experiencing.
Avatar m tn i started taking acyclovir a few days ago for the first time for a mild cold sore breakout. 2 days after i started, the cold sores got more intense, and 2 new huge cold sores came up out of nowhere. i have 3 more days left of the medication, and i'm going to keep taking it, but what should i do? these cold sores are not going away, and it seems like its getting worse! so done with these friggin things...
Avatar m tn Like most I cannot afford Valtrex any more. I have switched to Acyclovir. I've used it effectively for the couple of outbreaks but it seems to be taking considerably longer. I am taking L-Lysene as a suppressor and only take the Acyclovir at the first sign of an outbreak. I was taking 1000mg Valtrex at onset and then 500mg twice a day and everything was clear in 3 days. To get the same effectiveness from Acyclovir how much should I be taking daily during out breaks?
1302779 tn?1287405029 the doses you take for recurrences do tend to give the headaches :( do you take advil or anything along with the acyclovir knowing that it's likely to cause you to get a headache?
Avatar m tn Does Acyclovir make anyone else feel completely terrible? I get terrible headaches, dizzy, diarrhea and feel just awful. im not sure which is worse sometimes.
Avatar f tn When a medication is administered intravenously, its bioavailability is 100%. However, when a medication is administered orally, its bioavailability decreases because not all of it is absorbed. So 70% bioavailability means that, from the dose you took, 70% of it reached systemic circulation. "Two studies have been carried out to assess the effect of food (ie, a high-fat breakfast) on the bioavailability of a SINGLE oral dose of ribavirin. An initial study by ICN Pharmaceuticals, Inc.
Avatar f tn Also as a side note, Opana oral bioavailability is actually very low. Lower than morphine I believe the bioavailability is around 10 percent. However, if you reach your optimal dose, bioavailability matters little. I see that this post is from October 2011. But since I have this typed, I'll post anyway :) Good luck and gentle hugs.
1654177 tn?1319838494 Also best not to take drugs with lots of fiber as they can bind to the fiber and pass through the system before total absorption thus decreasing bioavailability. You need all the bioavailability you can get!.
Avatar f tn Blood tests are not accurate for testing the active bioavailability of sex hormones in the cells and tissues. They only test what's in the blood stream. They aren't accurate for testing when a patient is using bioidentical topical creams. I've had two holistic doctors tell me this and have read numerous articles about which testing is correct depending on which type of hormones you're taking.
Avatar n tn The ascorbate in Ferrous Ascorbate helps retardation or prevention of Fe(II) oxidation by ascorbate and to the existence of Fe(II) as a chelate with ascorbate ( vitamin C if you like ). Ferrous Ascrorbate will have a better bioavailability but you can add a vitamin C and vitamins B complex with sodium feredetate and have pretty good results. Depending on your needs; are you lacking iron? anemia?
1431734 tn?1421011671 The component of the final population pharmacokinetic model that describes the absorption phase is complex. Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h.
Avatar m tn Greatly simplified - you swallow valtrex and your body converts it into acyclovir inside the body. You get more active acyclovir available to kick a little herpes butt by doing it this way. That's why you take valtrex less often. We don't have studies to confirm that acyclovir reduces transmission the same amount as valtrex does but we assume it does. http://racoon.com/herpes/v_a_compare.htm this table comes directly from the valtrex full prescribing info.
Avatar m tn My guess would be because you get less active acyclovir in your body with plain ole acyclovir than you do valtrex but we have no studies to back this assumption.
Avatar m tn acyclovir is 400mg 2x/day every single day. she will still get recurrences while on daily suppressive therapy regardless of if she's on acyclovir or valtrex, you just take acyclovir more often than you do valtrex.
Avatar f tn The component of the final population pharmacokinetic model that describes the absorption phase is complex. Although a standard meal did not affect ribavirin bioavailability (F1), administration of ribavirin with a high-fat meal increased bioavailability by 46% relative to the fasting state. A high-fat meal prolonged the duration of the zero-order input part of the absorption model, with D1 increasing from 0.498 h (fasting and standard meal) to 0.740 h.
Avatar f tn s and viral shedding, the once daily doses of acyclovir were not effective. the half life of acyclovir is very short and just taking it daily is not enough to keep the virus under control adequately.