Acyclovir and renal impairment
Common Questions and Answers about Acyclovir and renal impairment
famvir
These dosing interval recommendations are based on modeling of single-dose pharmacokinetic data in non-HIV and non-HBV infected subjects with varying degrees of renal impairment, including end-stage renal disease requiring hemodialysis.
New Onset or Worsening Renal Impairment
Tenofovir is principally eliminated by the kidney. Renal impairment, including cases of acute renal failure and Fanconi syndrome (renal tubular injury with severe hypophosphatemia), has been reported with the use of VIREAD [See ADVERSE REACTIONS].
It is recommended that creatinine clearance be calculated in all patients prior to initiating therapy and as clinically appropriate during therapy with VIREAD.
It is likely the patient had acute colchicine toxicity brought on by the addition of erythromycin and superimposed on chronic colchicine intoxication secondary to renal and hepatic impairment. The patient improved with supportive therapy and intensive hemodialysis and was discharged on day 70 of hospitalization. Another report describes two fatal cases of agranulocytosis due to presumed interaction between colchicine and clarithromycin, a potent CYP450 3A4 inhibitor.
Elevated levels may be seen in kidney disease, muscle degeneration, and some drugs involved in impairment of kidney function. The normal values of serum uric Acid are 3.0 - 8.2 mg/dL.A normal BUN-to-creatinine ratio is between 10 to 1 .Your values seem to be in normal range. It is suggested to discuss your test results with your attending doctor and correlate them clinically. I sincerely hope it helps.
Best wishes and kind regards!
96 and now at 1.43. He has no renal impairment and his kidney ultrasound and detailed urine report is perfectly normal. He is cirrhotic (Hep-c) at stage 2 according to doc (hep-c) which stopped the sovaldi + ribavirin treatment to save his kidneys. However during the period he was also on diuretics (furosemide) occasionally. His nephrologist says that it is safe to continue sovaldi treatment but the other doc gave a red flag (I have yet to have a dicussion with the nephrologist).
Hello,
A clinical examination and work up is important for correct diagnosis and management.Fever, chest pain and congestion can be due to an infection like pneumonia. High fever can be a symptom of infection or septicaemia.Hypotension, hypovolaemia, angina all can cause chest pain. Since she is unable to walk a portable X-ray chest may be helpful. Blood tests and blood culture may be helpful.
While elevated ammonia levels are seen in cirrhotic patients there can be encephalopathy with normal ammonia levels and there can also be no mental impairment in some patients with elevated ammonia levels. Basically, ammonia levels are of limited use for diagnosing cirrhosis or hepatic impairment. I would also think some other results of your blood work would have been out of range if you are cirrhotic or are suffering significant liver impairment.
An elevated BUN [blood urea nitrogen] is concern for liver and/or renal impairment, not diabetes. Although I have empathy for your father, you are seeking help in the wrong place. Ask your father's doctor to refer you to a nutritionist or some who specializes in that degree in your country.
My father has mild kidney impairment from jump starting him after bypass. He takes lasix 80 mg BID and when his weight is up he takes 160 BID for 3 days. They have removed 1800 cc, then another 2 full bottles from the pleurovac (which I believe the bottle holds 600cc). Right now they are beginning aggressive physical therapy to see how he does then they will evaluate for other options.
Mannitol could be an issue since it is an osmotic diuretic agent and a weak renal vasodilator. The amount of mannitol in Copaxone is small and absorption
Gabapentin (Neurontin) should be used carefully in patients with renal impairment due to possible accumulation and toxicity. It has been linked with liver toxicity.
Provigil is metabolized by the liver and excreted in the urine.
Have they looked for an independent cause?
If these levels are unavailable (because the patient has been well and has had no blood tests) it is occasionally necessary to treat a patient briefly as having ARF until it has been established that the renal impairment is irreversible.
m a healthy 24 year old female who has been suffering from this since Spring 2007 (came down with meningitis 3x in 3 months - acyclovir and Valtrex treatments did not work and resulted in renal failure). All 3 times, my spinal tap came back positive for HSV II.
I am currently (and have been since August 2007) taking 500mg of Famciclovir per day. For the first year, I took 500mg 3x per day. The second year I reduced it to 500mg 2x per day because it was really hard on my body.
Rarely, patients with Wilson disease develop renal stones and associated symptoms. Renal stones are precipitated by hypercalciuria (the condition of elevated calcium in the urine. Chronic hypercalciuria may lead to impairment of renal function, nephrocalcinosis, and renal insufficiency.) and poor urine acidification. Therapy with copper-chelating agents can improve renal function.
There are preferred opiates drugs that are use in patients with liver disease that have shorter half-lives and have less harmful side effects on the renal system. Your liver doctor should be aware of these drugs and be able to determine if you may be able to use them.
With regards to OTC medications, normal recommended doses of acetaminophen can be safely given to patients who suffer from cirrhosis in the short term.
Wellbutrin XL should be used with caution in patients with hepatic impairment (including mild to moderate hepatic cirrhosis) and a reduced frequency and/or dose should be considered in patients with mild to moderate hepatic cirrhosis (see CLINICAL PHARMACOLOGY, WARNINGS, and PRECAUTIONS).
http://www.drugs.com/pro/wellbutrin.
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