acyclovir and methotrexate

I've had genital herpes hsv 2 for around 3 yrs..

I take methotrexate to treat lupus and a side effect of that drug is cold sores on my face. I've been taking 1,000 mg. acyclovir daily for over ten years and it seems to be losing its effectiveness in keeping the cold sores at bay. Has anyone else found that it doesn't work as well after many years? If so, what did you do? My rheumatologist said I can take up to five pills a day but I don't want to do that. Thanks for your help.

I have Rheumatoid Arthritis (RA) and was recently put on Methotrexate. After 8 weeks, I started developing symptoms, redness, burning, and pain down my legs, and my OBGYN diagnosed me with genital hsv-1 via a blood test and symptoms. I stopped taking the methotrexate, as I assumed the infection came out of dormancy due to a suppressed immune system, which is an effect of this drug. I took 500 mg of valtex 3 times a day for ten days.

I have been taking prednisolone on off for years for sinusitis/allergies and have read some people have started taking methotrexate for Rheumatoid Arthritis. Does anyone know if this would also work for chronic sinusitis conditions?

My husband has ankylosingspondilitis and takes enbrel injections and has considered taking methotrexate before. Best of luck. Could be a real blessing from God :) and a healthy baby!

ive recently been on flucloxicillin and penecillin very high doses and i know this can affect mtx strengths. i have been tired and achy and nauseas for weeks now. ive done two hpts and both have been negative. should i see my gp?

My daughter was diagnosed with Behcet's in 2008. Then in 2009 she contracted herpes (hsv2). She is now having an outbreak of herpes (starting to get under control after 2 rounds of valtrex, back on acyclovir for 2 days) and a flare of Behcet's. Prednisone will make the painful vaginal Behcet's lesions go away but will cause another outbreak of herpes. Does anyone have any suggestions? She's about to leave for a required college trip. Thanks.

The prednisone step doown depends on how long u have been on it typically the longer your on it the slower the step down as well as strenght so a doc is nest to ask but it could be fine since it was such a short time. As for methotrexate I found 2 articles on it and GM and it sounded promising and my breast doctor agreed and sent me to a rheumatologist to monitor the drugs and my docs communicate about my progress and work together.

My doctor was referring to a study wehre Acyclovir slowed disease progression in HIV by reducing viral load. And so he thought Acyclovir might have a direct effect (even if it is low) on HIV. Maybe he thought that by decreasing viral load antybodies would show up later than in the absence of Acyclovir?

My primary care physician and rheumatologist advised me to stop the methotrexate immediately. Methotrexate injures the liver, and that is why it is dosed once a week instead of daily. This gives your liver time to heal in between doses. Methotrexate was very effective for my RA symptoms and I hated to give it up, but I wasn't willing to destroy my liver in order to get relief from joint pain.

Can the Methotrexate alter my thyroid levels? I am off Methrotrexate now and only taking 5 mg of Predisone and 175 synthroid?

Once and awhile I will get a migraine often accompanied with with a scalp breakout and I stop taking the Acyclovir and lysine until the pain goes away. Then I resume my acyclovir and lysine. I now rarely have any problems. But I always have to go a week once and a while without my Acyclovir and Lysine. Is the herpes virus simply one of my triggers or is the herpes virus the root cause off all my migraines, I don't know. The pain and breakouts are always hemispheric in nature.

So sorry to hear you are in the same boat as me. I have very similar pain and I have a positive ANA one time and negative the next time and the same on the RF. It sounds like, as in my case, it is RA or Lupus. For me it is gearing more to Lupus since my pain is mostly in my muscles and connective tissue, not my joints. I'm rather surprised he would start you on methotrexate without a diagnosis. How long have you had these issues? How long have you been on your meds?

The methotrexate injection is a significantly less risky and less costly therapy, and I would have done the same thing. It won't deplete your entire folic acid stores--the dose used for treating ectopic is pretty low. And methotrexate works preferentially on rapidly growing tissue, not on stable tissues. I hope your therapy works--in your case there is a very good chance that it will.

We had an ultra sound and it showed fluid in my left tube. I received Methotrexate to abort the pregnancy on Sept 6 and I have continued taking metformin. My doctor has requested we wait three months to TTC again. We are so ready to try again! My question is has anyone else been through this? If so how long did you wait to TTC and how successful were you?

Not sure that in USA methotrexate is mandated with rituximab for RA, and the studies she spoke of to us were US-FDA trials. So there may actually be another reason, but as no further funds went into the US Rituxan trials, perhaps we will never really know the total reason? Sounds like following it up might give valuable clues.

Few Lesions (pimple like with red base) come and go everywhere in my body (cheeks, forehead, ear pinna, eyelids, chest, arm, forearm...). I have took acyclovir only for 10 days in October and am suffering a couple of lesions coming up and clearing in few days every now and then. This is companied by random itching occurring in different parts of the body without visible lesions, I also felt some shooting pain for a few seconds (rarely) into my penis.

She was a teacher and had to take the methotrexate over weekends because it made her so nautious and fatigued. She is an on the go person and didn't tolerate "being out of action" very well, so she opted to rather go for high doses of cortizone (which of course has serious long term consequences). Today she is having serious problems with her immune system failing, as well as her heart and kidneys.

Sorry for all that you have been through. Good days are ahead foryou,I just know it. If you ever need someone to talk to feelfree to email. God bless and you'll be in my thoughts and prayers!!

I had an ectopic pregnancy about a month ago. I was given Methotrexate. My levels have been checked, they are going down. How long until I'm out of the clear? My doctor is horrible. She told me I should expect bleeding like a heavy period. I've been bleeding heavily for a week. When is this going to be over??

I feel for you and can relate. My son has been 48" tall and about 48 lbs for about four years. The meds for this are scary. You have to trust your instincts. Insist the docs follow your son closely by doing and reviewing blood work often...no less often than every three months. We have been "climbing the medication ladder" ourselves: Pentasa (oral), 6MP (oral), now Remicade (infusion). Each one of these is great, when it works.

I certainly understand your reluctance to continue on with methotrexate. I'm an RN (disabled now) and was working when I was diagnosed with RA. Naturally, I looked it up in the drug reference books and was also scared. My rheumatologist explained that this is one of the older and more reliable treatments for RA and would be worth the risk for me to prevent/delay the crippling effects of the disease. Very smart of you to go to the ER for those kind of troubling symptoms, though.

Acyclovir and methotrexate

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