[copy/paste] "For reasons still not identified, the long-term use of Actos weakens the respiratory tract’s immunity. This results to throat and respiratory infections like sore throat, sinusitis, coughs, and colds." Use with caution if you have heart issues. Also, Avandia is the other drug that falls into this classification. The FDA warns not to use Avandia for first time users, in fact, the FDA severely restricts its use.