Estrogen patches are generally a safer choice. Implantable estrogen, a recent development, is probably safe, but long
studies as to its effect on liver disease have not been done. Soy estrogen, originally thought to be a safe alternative, should be avoided, as recent reports have suggested that it may cause drug-induced hepatitis.
Biphosphonates are phosphate derivatives that bind to the surface of the bone, thereby blocking bone removal and decreasing bone loss.