a pharmacokinetic comparison of pregabalin and gabapentin

I was on 1800mg a day and put on a stone over 4 months! I have now swapped to pregabalin and I am beginning to lose the weight. I changed drug because the Gabapentin was not controling my symptoms enough nothing to do with the weight gain, I am now on 400mg of Pregabalin and I am try to lose the weight I have gained so far I have lost half a stone in about three weeks. I know that there are many people who feel that Pregabalin also makes them put on weight.

At the consultants appointment today a number of things were resolved having only seen the registar the appointment before, which really was a waste of time, this was far more productive and has left me with a few questions to ask the forum members, but as they are quite diverse from one another I'll do them as seperate questions.

If given a choice without cost factors pros and cons of Gabapentin versus Lyrica for long standing neuopathy pain in my back, legs and feet from surgery over 10 years ago...Any advise appreciated..

Thanks Lulu, Have been to GP and blood test for sarcoid is negative. Really pleased about that. He has given me the plan to swap from Gabapenten to pregabalin. This means to begin with lowering the gabapentin dose by 300mg every 3 days (I'm on 1800mg at the moment) and then when I'm down to 600mg of gabapentin a day I start to add the pregabalin 75mg to begin with then upping it every 3 days till I reach 300mg a day at the same time still reducing the gabapentin to zero.

Gabapentin is not a narcotic and is not a substitute for opiates like Oxycodone. Opiates are still the best pain control medications available. Gabapentin (Neurontin) and pregabalin (Lyrica) are similar medications that modulate pain transmission in the nervous system, but gabapentin and pregabalin utilize a different chemical pathway than opiates.

If I am calculating your dose correctly you are on 600mgs of a Gabapentin. This is not a high dose and you may want to discuss an increase of the Gabapentin with your physician. There are other similar medications that may be more beneficial too. This is a discussion that needs to be between you and your physician. The journey through Chronic Pain is not easy.... but with a good physician and the right medications it can be easier. I hope you will find a solution to your increasing pain.

Just to add a ditto to Selma. I too was on gabapentin for a while, it upset my stomach awful and I just didn't feel good taking it, so I switched to its cousin, pregabalin (Lyrica) and I did just fine with years of taking it. Both drugs almost overnight stopped the severe pain in my lower spine, so if pain is still your issue, then pehaps Selma's thoughts would work for you.

My consultant asked my GP to over see the swap over to Lyrica. So this is the plan. This means to begin with lowering the gabapentin dose by 300mg every 3 days (I'm on 1800mg at the moment) and then when I'm down to 600mg of gabapentin a day I start to add the pregabalin 75mg to begin with then upping it every 3 days till I reach 300mg a day at the same time still reducing the gabapentin to zero. Hope that makes sense.

Gabapentin is a class of drug known as a GABA analogue. GABA is an abbreviation for gaba-amino-butiryc-acid, a chemical neurotransmitter that helps induce sleep in the brain. GABA also reduces nerve impuses, which is why it works for neuropathic pain. While gabapentin is not GABA, it mimics its action, and creates drowsiness.The side effects are dose dependent, so please report your side effects and ask your doctor for help. Perhaps a reduced dose might help you with the drowsiness.

m not hopeful that increasing the dose or frequency of gabapentin will help. What can I do? Ease off gabapentin, take an itchy break of a few months, and ease back into it? I want relief! Suggestions welcome!

I realize this is a very difficult type of pain to treat, but wonder if something stronger and/or of a different combination might be worth trying to achieve greater relief. Could you comment briefly on the mechanism of action in the above meds and which ones are typically most effective, with the most tolerable side effects? Also, are there other established or experimental meds for MS pain that you would recommend pursuing? Thank you.

I take both Gabapentin 3 x a day at 300mg (although neuro has suggested increasing htis as symptoms not udner control) and Amitriptyline 10mg at night as I found 20mg at night knocked me out and I needed 10 hours of sleep a night to function. The present does suits me fine..but we are all different and I think you just have to find the right dose for you with the support of your doctor.

The gabapentin is because 600mg is the maximum allowed dose of pregabalin (in Australia), and by taking gabapentin at night I can squeeze a few more hours of lower pain out of the day. Gabapentin's only real side effect has been a little queasiness. Unless you have one of the severe reactions like rash - and that one is a major warning - giving either one of the two drugs a month or two is probably a good experiment.

This is true of gabapentin and pregabalin which were originally invented for seizures. Pregabalin is similar to gabapentin but has less side effects and often people who can not tolerate gabapentin benefit from pregabalin. However it is more expensive. The same is true for medications such as amitryptiline, which was originally used for depression but is now a mainstay of treatment for neuropathic pain. However, it has several side effects and may not be used in patients with heart problems.

Lyrica works to control nerve pain and is approved to treat fibromyalgia. Lyrica is a trade name and Pregabalin is the actual name of the medication. Lyrica is a hybrid, so to speak, and similar to gabapentin or Neurontin. Neurontin is approved for use to treat seizures but was found to be helpful with individuals with fibromyalgia Savella is a dual reuptake inhibitor called a SNRI. Which means is it a serotonin-norepinephrine reuptake inhibitor.

m on 25mg twice daily and was on 600mg of gabapentin and now down to 1200mg a day....I really think this drug is perfect for people with bipolar.....It has worked so well for me..

The antidepressant efficacy and favourable tolerability and pharmacokinetic profiles of tianeptine in patients with depression, including those with associated anxiety, have been proven; the data indicate that it may have additional potential in specific subgroups of depressed patients such as the elderly and those with chronic alcoholism.

Hello melal, It seems that you are having nerve compression due to the impact on the wrist.

I used the hydromorphone to get off of fentanyl which Id been addicted to for 2 years. So I badly tapered of the hydro, and have been self medicating with gabapentin to nullify my withdrawal symptoms (about 2400mg 2x a day is what I've found at this point works best after establishing a tolerance).

I have recently seen my Neurologist, who has confirmed I am suffering with Anxiety and has suggested I go on a drug called Pregabalin and he has said it will help my sleep problem. My question is has anyone had any experiences with this drug, if so comments very welcome.

Dear Stukls, Thank you very much for your question. I am happy to address the issues that you pose, although it is important that you recognize that my impression is based entirely on the information you have provided in your posting and is by no means a replacement for an office visit with a neurologist. Diagnosis is contingent on detailed history and physical exam and as such, the following information should be considered solely for educational purposes.

I was finally diagnosed with the condition after 2 years of trying various prescription topical creams (Elidel, Pramascone, Steroid Creams, Anti-fungals etc.) and oral medications (Pregabalin, Gabapentin, etc.) Is there any procedure I must have done to confirm my condition? Is there any particular specialist besides a dermatologist who would treat this condition? I have been to several dermatologists and most are clueless of the condition.

Other drugs like gabapentin, pregabalin, amitryptline, carbamazepine are also effective and are relatively safe as compared to nortryptline. For more information visit http://www.drugs.com/nortriptyline.html http://en.wikipedia.org/wiki/Nortriptyline http://www.patient.co.

Due to the proximity of the symptoms and the intake of tamoxifen, it can be assumed that these side effects may be indirectly related to your intake of the tamoxifen. I understand your doctor in trying to control and try different ways to control the pain rather than to stop the tamoxifen altogether since you would ultimately derive benefit from tamoxifen treatment.

They are not going to stabilize a sad mood, they will prevent anxiety and panic attack which are destabilization of a normal mood therefore stabilize a normal state of mind.

A pharmacokinetic comparison of pregabalin and gabapentin

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lyrica