Dear Just Need,
Celaxa can occasionally have the side effects you have, a sense of paranoia and
depersonalization. I can tell you this, the diff antidepressant
Zoloft in particular is used to specifically also help with panic disorder and anxiety, so instead of Celaxa, if your doc will switch, try it. If you do, also consider trying it at a rather low dose for awhile, maybe 100mg daily, split in half and used breakfast & dinner, at least at first.