The simple answer to the question 'can Zoloft
cause permanent tinnitus' is yes, and that goes for for
all the SSRI's. According to Dr Stuart Shipko, who runs a panic disorder clinic in CA, Zoloft is the worst of the lot though. He does warn that STOPPING taking the SSRI may make the tinnitus even worse though, so if you've been on it for some time, perhaps you'd be better off staying on it, if it's working for you. I only took zoloft once.