I take 200 mg Zoloft for depression and Klonipin for anxiety and Celebrex for arthritis. When I first wake up at 3:00 am, I feel sort of ok, that's when I take my Zoloft, Celebrex. After a few hours, I feel extremely tired, depressed, suicidal, so I start taking caffeine so I can go to work. I take enough caffeine that I get the jitters, but then I can pretend I'm ok, but it bothers my stomach.