My experience with zoloft was, that taking 50mg a day, I at first lost a few pounds, and was ecstatic. I've struggled with severe anxiety, and the zoloft really helped me. However, after about two months of being on it, I began to gain weight steadily, until I had packed 15 extra pounds on to my small frame. I never had ANY trouble with weight gain in my life; if I started seeing the scale creep up, I could exercise and be careful for a day or two and it would go right back to normal.