Zofran comes in either 4mg or 8mg, and comes either as a pill you swallow or as one you dissolve on your tongue. I had really severe
nausea with vomiting
and was given the 4mg dose of
Zofran in the dissolving form. Each time I took it the nausea and vomiting stopped completely within about 15 minutes, and in another 15 minutes I was actually feeling hungry and wanted to eat. The instructions said every 8 hours as needed, but I only rarely needed to take a second dose layer in the day.