Ziprasidone pharmacokinetics
Common Questions and Answers about Ziprasidone pharmacokinetics
geodon
Hi all. I am currently taking ziprasidone along with lamictil and topamax and Lexapro as well as an occasional Ativan. I have been taking 80mg ziprasidone-geodon- twice a day for almost three years now. It has made me gain almost 200 pounds! I need to get off of it but Everytime I do I start the withdrawal. Has anybody else been on geodon this long and gained so much weight? I even exercise and can't get it off.
(have been on said meds for about 5 years). her 2 suggestions are abilify and ziprasidone--i know nothing about either of these meds and would greatly appreciate any info. and input you may have. (i have until friday to research these meds and want to be as informed as possible) thank you very much in advance for your time.
- Absorption, oral: time to peak concentration 7h
- Elimination half-life = 12 h
(It says also that in general it can be administered once daily because it has a 24 h effect.Why?)
- Can you give another example to clarify it better please?
- When it says divide in 2 doses , does it mean only in the morning and dinner? 3 doses (morning-lunch-dinner)?
Thank you for taking the time to answer!!
Hi. I'm bipolar with psychosis and am currently tapering off of ziprasidone 80mg twice daily. I totally dropped my second dose along with lamotrigine,and Lexapro. So right now I am currently taking ziprasidone 80 mg, chantix 1mg, topamax 50mg 3x day, and ropinirole for side effects 1 mg once a day. I can't believe I actually made it through the night last night.
It also slightly increases the QTc interval in some patients and increases the risk of a potentially lethal type of heart arrythmia known as torsades de pointes. Ziprasidone should be used cautiously in patients taking other medications likely to interact with ziprasidone or increase the QTc interval.
She is currently taking Cymbalta, Lamotrigine, Seroquel and Ziprasidone. She has been depressed for a few years but it suddenly got worse since she started to take ziprasidone. She has been taking it for about 2 weeks now. She informed us that she is hearing voices telling her to harm herself. She has experimented in cutting in the past, but yesterday she did it to the extreme resulting in numerous cuts to her arm. Is taking these four medications together a detriment to her mind set?
1X DAY, 5) VALACYCLOVIR 500MG 2X DAY, 6) ZIPRASIDONE 80MG. 2X DAY, 7) BUSPIRONE 15MG. 2X DAY, 8) METOPROLOL 25MG. 2X DAY, 9) THEOPHYLLINE 300MG. 2X DAY, 10) METOCLOPRAMIDE 5MG. 4X DAY, 11) LEVETIRACETAM 1,000MG. 3X DAY, 12) DIVALPROEXE 1,000MG. 3X DAY, 13) VIMPAT 100MG. 2X DAY, 14) ZONISAMIDE 100MG. 3BEDTIME, 15) LANSOPRAZOLE 30MG. 2X DAY, 16) SUCRALFATE 1GM. 3X DAY, 17) COLESTIPOL 1GM. 3X DAY. I'VE TRIED VIAGRA BEFORE WITH NO RESULTS. I WAS ON WELLBUTRIN BEFORE ZIPRASIDONE.
Ziprasidone (Geodon) is a medication that must be withdrawn from very slowly. I would urge you, STRONGLY, to seek the advice of a qualified physician to help with this procedure. If you are unable to afford a doctors visit, please consult your local pharmacist in helping with your daughters withdrawl. Pharmacists are DOCTORS OF PHARMACOLOGY and can tell you the correct way to proceed. Please do not attempt this on your own.
A friend of mind took 1200 mg of ziprasidone should I be worried? I don't think it is correct. Please let me know, I have been looking but can't find anything on that amount. She needs help, she is not in a good place right now.
Besides Clonazepan, Solof, Lorazepan, Divalproex, Citalopran, Donepezil,Divalproex, Enalapril, Carb/Levo tab she started taking Ziprasidone four weeks ago.Please tell me if she should stop taking some of those medications.
Cool , that's great new's them finding the right dose for you , sometime's that's all it take's instead of switching from med to med . Are you sleeping better now ? . As for Risperdal quiet a few people have problem's with weight gain from that drug i did also , but i found it more effective in smaller dose than higher because i got other side effect's at a higher dose simmilar to the Ziprasidone.
About a month ago I was able to lower my self off of paliperidone and onto ziprasidone which is the same category of drug as paliperidone but studies have shown that out of all antipsychotics ziprasidone had the least amount of weight gain. So I’ve been on ziprasidone for about a month now and I’m still losing weight while walking. Sometimes after my walks I only accumulate around 100 calories a day. On days that I splurge a bit and take in around 800 calories a day, I gain weight though.
They gave me Depakote Er divalproex sodium 500mg and also Geodon ziprasidone HC 40mg for the pain they told me it would help me out for the pain I was going throw. I started looking the pills up on the internet and found out they where used for people with Bipolar issue.
I can't help out on the pharmacokinetics, but your reasoning is sound: it doesn't make sense to dose so that the drug runs out.
I'd query Schering-Plough as well as your hepatologist, if I were you.
Please give me a heads-up if you solve the riddle.
Any medication can sometimes take a week or two or longer to take full effect while some will take effect instantaneously. It all depends on the person of course. When I took Geodon I sometimes would "drool and stumble" figuratively for the former (felt really dumb some days) and literally for the latter (dragged my feet and sometimes felt drunk).
I didn't notice any weight gain but again, everyone is different.and it isn't really know for that like ziprasidone(Zyprexa) is.
Hepatic Impairment
In volunteers with hepatic impairment (Child-Pugh Class A and B), sildenafil clearance was reduced, resulting in higher plasma exposure of sildenafil (47% for Cmax and 85% for AUC). The pharmacokinetics of sildenafil in patients with severely impaired hepatic function (Child-Pugh Class C) have not been studied. A starting dose of 25 mg should be considered in patients with any degree of hepatic impairment [see Dosage and Administration (2.5) and Clinical Pharmacology (12.3)].
Folic acid supplementation in folate-deficient patients with epilepsy changes the pharmacokinetics of phenytoin, usually leading to lower serum phenytoin concentrations and possible seizure breakthrough..."
It however says that initiation of Folic acid and phenytoin together is beneficial.
Since you can't go back and start all over again, you can take a small dose. It has been observed that as los as 1mg dose can perturb phenytoin’s levels, You may take doses lower than 1mg/day.
I've noticed 3 days taking just 40 mg. per day of Ziprasidone (Zeldox) that my vision is very blurry (my eyes are bad at the best of times - wear special contacts & glasses) so this is very bothersome. It's listed on another site as a Common side effect, not an uncommon one....but I can't seem to see if it eventually goes away?? Would appreciate any comments ASAP before I see my doctor soon.
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