A somewhat unusual or unexpected strep
infection is perianal disease. This presents as an intensely red
rash around the anus, which is usually mistaken for a yeast infection (Candida). However, antifungal medications such as nystatin cream are useless. The rash disappears promptly with oral penicillin or erythromycin treatment. Intertrigo, infection of moist crease areas, is most often due to Candida albicans (yeast) infection. It may however be caused by Group A Streptococcus, as well.