So, I took my first dose of Suboxone yesterday, and my last dose of Ultram was about 550mgs, 12 hours before that. I had no idea how the Suboxone would make me feel, since Ultram is not a "complete" opioid. Well, here is what I have pieced together so far. Ultram is a triple threat, meaning that parts of it act on the mu opiate receptor, part of it is an SSRI, and it is ALSO an SNRI, which means it produces Serotonin AND Norepinephrine.