Hey,
what I hear
is that the skin eventually gets
used to the injection. Mine did - after a month or so, it stopped creating the welt.
The most important thing to watch with Copaxone is the lipoatrophy. Proper rotation of the injection sites will help prevent that, but like many of you, I found that certain sites were difficult or impossible to inject regularly. And if I had an IPIR, I would stop using that area, so eventually the only safe spots were my hips, my thighs, and my stomach.