It is difficult to find those long-term use studies that identify
what the medicine
does to the body, rather they focus on
what it
does to the disease. So, is harder to find.
What I can say initially though is, complications of the body from DMDs typically stops once medicine is stopped. i.e., those who liver enzymes rise from interferon, see it fall back to normal, those w/high blood pressure from the oral, return to normal as well.