warfarin in liver disease

The new research looks at how warfarin affects the progression of fibrosis in mice with chronic liver injury. Warfarin is already used to prevent and treat blood clots in people with artificial heart valves, deep vein thrombosis, and a host of other conditions. A previous study by the same researchers demonstrated that in Hepatitis C, scarring of the liver accelerates in those patients who are prone to form blood clots.

Hi, I was diagnosed with Pulmonary Embolism 3 years ago with hypercoagulability (genetic) and have been on 2.5mg of Warfarin per day for the past 3 years. I have just had an abdominal scan, and was told that I have a dense, fatty liver. I have tried to eat as healthy as possible, but had to cut a lot of greens out of my diet, as it affected my INR and would have lead to me having to increase my Warfarin dosage. Now I am not sure if this lead to the 'fatty liver'problem.

Warfarin works by reducing clotting agents present in the blood which means you are more prone to bleeding. You should watch for blood in your faeces and try not to bruise yourself too much. It is also a good idea to have regular blood tests for checking Liver function. Are you on Warfarin long term?

So it was deliberately developed as an anticoagulant and it was found to have other uses, such as saving lives in humans suffering a thrombus. Warfarin would affect just about any living thing with a blood stream, so it isn't really just rat poison.

The risk of bleeding may be increased. Conversely, reductions in INR/PT have also been reported in chronic alcoholics with liver disease. The proposed mechanism is that continual drinking of large amounts of alcohol induces the hepatic metabolism of anticoagulants. Effects are highly variable and significant INR/PT fluctuations are possible.

All the drugs you mentioned might cause problems only if you are in end stage liver disease and very extensive liver damage is present. Your labs show that this is not the case. Even with extensive liver damage all these drugs still can be used, but the dosages would have to be lowered. Anesthesia and contrast also can be safely used in patients with liver disease. The liver is very resilient and really can take a lot. Wish you the best and hope for a good outcome of your surgery.

Blood clots that form in veins (deep vein thrombosis, pulmonary embolism) are mainly made up of clotting proteins and platelets do not play a significant role in venous clots. Coumadin or warfarin is an effective blood thinner that prevens the production of clotting factors in the liver. Anti-platelet drugs like Aspirin or Plavix do not play much of a role in preventing venous clots.

Seven months ago I had a pulmonary embolism and I am told this may have been the second one.I am taking 7 mg of warfarin a day and my INR is 2.5.I had a liver transplant 10 months ago,and was told my vascular system was not great.Given my overall situation I am concerned about heart attacks and strokes.Do you think I should be taking 75mg of aspirin a day as well as the warfarin?Thanks.

Worry about maintaining an INR that is consistently within range. Whatever dose of warfarin you have to take to stay in range is okay.

Standard cod liver oil is *extremely* high in vitamin A, and there is some chance that taking excess vitamin A--over a teaspoon per day--will increase the effectiveness of coumadin, putting patients at even greater risk for bleeding. Same goes for the Omega-3s in cod liver oil. You can read about it here (or wikipedia, etc): http://www.livestrong.

Im concerned about proarrhythmias and toxicity. High Warfarin dose and resistance to remain in sinus suggests to me that Id need quite a high sotolol dose too. I asked to go on pradaxa - dabigitran etexilate - as Im concerned about calcification, which I already have in shoulder. 2 cardiologists, an electophysiologist and my GP all denied any knowledge of the vitamin K / Calcification mechanism. I wasnt given a thyroxin test ever, I.V. Magnesium or urine test on presenting with af.

Does anyone know if Warfarin can cause elevated liver enzymes. Blood tests showed mine were both 45, but the doctor is not concerned.

Granted, it is possible to use so much fish oil that it could cause the same increased risk of brain hemorrhage that warfarin did in the study mentioned above. But you'd have to take 5 to 6 tablespoons daily for this to be a significant risk—and I don't know anyone who can swallow that much (it's not the tastiest stuff, so if you have trouble getting it down, you can blend it with rice or almond milk). For blood-thinning purposes, Dr. W.

In the case of occasional atrial fibrillation, would the use of blood thinners be necessary for a patient with historically low platelet count?

This is more of a question about Warfarin, Plavix, blood thinning treatment ect... I was swimming yesterday with my kids and was rubbing my eyes a good bit. Afterwards my wife noticed my left eye was bleeding, not pouring blood but there is blood in the white part of my eye. Doesn't hurt or bother me it's just a nice size blood spot. I've been on Warfarin and Plavix and a daily baby aspirin for over 6 months to treat my heart disease.

). Warfarin is best suited, in areas of slowly-running blood, such as in veins and the pooled blood behind artificial and natural valves, and pooled in dysfunctional cardiac atria. So common clinical indications for warfarin use are atrial fibrillation, the presence of artificial heart valves, deep venous thrombosis (clots), and pulmonary embolism (where the embolized clots first form in veins).

I have a friend who lay on the floor and felt a bump. It turned out it was her liver and she had fatty liver. Not saying you had that, just thinking it might be a good way to see if yours is swollen completely unscientific. I am just a fellow patient like you. To help your liver you could try just drinking water, that would help quite a bit. Has your doctor done any blood work? to check your liver function? Just trying to kind of think out loud here.

Yes, the prophylactic administration of isoniazid (INH) for a TB chest conversion may cause inflammation of the liver, but does so in a minority of individuals taking the medicine. However, there is also the risk of liver inflammation due to the medicine Crestor® (rosuvastatin) and it is conceivable that there could be an additive effect of Crestor® (rosuvastatin) and INH. In addition, niacin may increase the risk of muscle disease called myopathy when used with Crestor® (rosuvastatin).

Hi We have to rule out a bleeding problem here caused by bleeding disorders which may involve blood clotting mechanisms in the body. Does your husband take aspirin, coumadin or warfarin? Platelet count, INR, PT and aPTT may be determined to help rule out any underlying disorders. Other differentials are inflammatory disorders of the kidneys. Glomerulonephritis may be considered here if bleeding presents with no other associated symptoms.

Sometimes aspirin is used in place of the Plavix, and the patient will be on aspirin and warfarin. That type of combo regimen is used when the doctor doesn't think that one drug alone is enough to do the job, and one drug obviously wasn't enough in your case. It seems that your Plavix and warfarin regimen is working, so I'll join you in giving thanks for that.

I started 5 mg of warfarin on friday..today is sunday and i am seriously considering not taking my dose today at 10am. I started my schedule for taking it at 10am daily. When i took my first dose friday at 10am later that day right around 3 or 4 i started experiencing intense upset stomach.

Portal vein thrombosis (PVT) is a vascular disease of the liver that occurs when a blood clot occurs in the hepatic portal vein, which can lead to increased pressure in the portal vein system and reduced blood supply to the liver.

They are used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage, and vitamin K status. PT measures factors I, II, V, VII, and X. It is used in conjunction with the activated partial thromboplastin time (aPTT) which measures the intrinsic pathway. The reference range for prothrombin time is usually around 11–16 seconds; the normal range for the INR is 0.8–1.2. Clinicians desiring therapeutic anticoagulation may aim for a higher INR - in many cases 2.

Mike H thought it would be a good idea for me to post this link to the Warfarin study. I've been on it since Aortic Valve replacement in 1993..........I did not know I had Hep C until 2002, so all those years, I drank like a Sailor, and even after I found out, I continued to imbibe, I just cut way back. As Mike said, this is a very interesting study. It could be that my Warfarin usage has protected me all these years.

Both Diovan and Metopropolol can elevate liver enyzmes. The normal range for AST=SGOT, ALT=SGPT are 10 - 42. This is the range my doctor uses. Your just barely above the high end normal number. This is most likely due to your medicine, I would not be concerned with this small elevation. Just make sure you have liver test done periodically, to monitor any changes.

Factors such as aging capillaries or thinning skin, and even certain diet supplements and medications( aspirin, warfarin, etc) may cause easy bruising. Bruising may also indicate something more serious, such as a blood-clotting problem or a blood disease. If it persists, have this evaluated further for proper management. Blood tests including platelet count may be done. Once a bruise has formed, not much can be done to treat it. Most eventually disappear as your body reabsorbs the blood.

Warfarin in liver disease

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