warfarin and liver damage

All the drugs you mentioned might cause problems only if you are in end stage liver disease and very extensive liver damage is present. Your labs show that this is not the case. Even with extensive liver damage all these drugs still can be used, but the dosages would have to be lowered. Anesthesia and contrast also can be safely used in patients with liver disease. The liver is very resilient and really can take a lot. Wish you the best and hope for a good outcome of your surgery.

The researchers hope that treating these patients with warfarin will prevent this liver damage and improve their prognosis. Transplant patients have a liver biopsy every year following transplantation to assess their progress, and the researchers will analyse data from this biopsy to establish the effectiveness of the warfarin treatment.

Steve, Thanks a million for posting this link for others. Just had a friend undergo a liver & kidney transplant last week and I'm going to share this link & information with her Surgeon. Any more information you know about would be greatly appreciated. Do most patients that develop cirrhosis of the liver due to drinking, end up getting Hep C? If so, can you explain why?

Seven months ago I had a pulmonary embolism and I am told this may have been the second one.I am taking 7 mg of warfarin a day and my INR is 2.5.I had a liver transplant 10 months ago,and was told my vascular system was not great.Given my overall situation I am concerned about heart attacks and strokes.Do you think I should be taking 75mg of aspirin a day as well as the warfarin?Thanks.

He was developing severe tiredness and hand pain. He was investigated by cardiologist and was administered for Warfarin Sodium treatment; since the heart turned weak and one of the chamber was accumulating blood clot. He was regularly (initially weekly and then bi weekly and now monthly) tested for PT/INR response to the drug. But, on routine check up it is diagnosed that his SGPT and SGOT Levels have touched alarming.

Hi, I was diagnosed with Pulmonary Embolism 3 years ago with hypercoagulability (genetic) and have been on 2.5mg of Warfarin per day for the past 3 years. I have just had an abdominal scan, and was told that I have a dense, fatty liver. I have tried to eat as healthy as possible, but had to cut a lot of greens out of my diet, as it affected my INR and would have lead to me having to increase my Warfarin dosage. Now I am not sure if this lead to the 'fatty liver'problem.

t advise you on stopping medications, you should talk to your doctors about that one but niacin and verapamil can increase liver enzymes and are worth asking your doctor about. I hope this helps.

ve run many of these tests and have found that 2 to 3 tablespoonfuls of cod liver oil daily were always enough -- and not too much -- to do the job. Remember: Whenever you take supplemental oils or essential fatty acids, always take extra vitamin E, as mixed tocopherols, to prevent the oils from oxidizing too rapidly in your body. Take 800-1,000 IU of vitamin E with 2 to 3 tablespoons of cod liver oil each day.

They are used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage, and vitamin K status. PT measures factors I, II, V, VII, and X. It is used in conjunction with the activated partial thromboplastin time (aPTT) which measures the intrinsic pathway. The reference range for prothrombin time is usually around 11–16 seconds; the normal range for the INR is 0.8–1.2. Clinicians desiring therapeutic anticoagulation may aim for a higher INR - in many cases 2.

0), age ≥ 65, highly variable INRs, history of gastrointestinal bleeding, hypertension, cerebrovascular disease, serious heart disease, anemia, malignancy, trauma, renal insufficiency, concomitant drugs (see PRECAUTIONS), and long duration of warfarin therapy. Regular monitoring of INR should be performed on all treated patients. Those at high risk of bleeding may benefit from more frequent INR monitoring, careful dose adjustment to desired INR, and a shorter duration of therapy.

In a conflicting report, the effects of acute and chronic dosing of APAP on warfarin pharmacokinetics and pharmacodynamics was studied in 20 healthy males in a 2-phase, randomized, crossover study. The mean serum concentrations of S- and R-warfarin did not differ significantly between treatments. There was no change in anticoagulation response between treatment and control (4). INR should be monitored more closely when APAP use exceeds 2 g/day or chronic use > 7 days occurs. References: 1.

Great site! I've bookmarked it for future reference. Thanks for the information.

s never a good idea to switch from Coumadin to cod liver oil without the advice of a physician skilled and knowledgeable in nutritional and natural medicine. To find one near you, contact the American College for Advancement in Medicine You can also get lemon flavored fish oil with E. I use it and it's just a lemon flavor!

I had a surgical procedure last Thursday that required I stop all anticoagulant (warfarin) and aspirin (low dose) 5 days before the procedure. I recall my cardiologist being uncomfortable with the length of time I would be without clot prevention medications. I have permanent atrial fibrillation, so my heart is in the clot production mode 24/7. I have been back on warfarin and aspirin for two days and believe my INR is back in the 2-3 range.

Warfarin is best suited, in areas of slowly-running blood, such as in veins and the pooled blood behind artificial and natural valves, and pooled in dysfunctional cardiac atria. So common clinical indications for warfarin use are atrial fibrillation, the presence of artificial heart valves, deep venous thrombosis (clots), and pulmonary embolism (where the embolized clots first form in veins).

Given that yesterday he said to not take the warfarin he was changing me from the genertic warfarin and putting me on the brand name of the med coumadin. Said some folks do not tolerate warfarin well but do well on coumadin and i am to start the coumadin today. I would be lying if i didn't say i am a bit gunshy at this point. This med has made me absolutely miserable and today is my 43rd bday...

Thrombosis can be prevented with heparin administration and treated with heparin and warfarin. If clots occur heparin followed by warfarin ( coumadin )is usually prescribed. Higher-than-usual doses of warfarin may be needed. Warfarin or Coumadin is prescribed to prevent strokes arising from atrial fibrillation and DVTs forming in the legs usually.

People can have elavated readings but have little or no damage and you can have normal readings but have damage.

Enhanced hypoprothrombinemic response to warfarin has been reported in patients with acute alcohol intoxication and/or liver disease. The proposed mechanisms are inhibition of warfarin metabolism and decreased synthesis of clotting factors. Binge drinking may exacerbate liver impairment and its metabolic ability in patients with liver dysfunction. The risk of bleeding may be increased. Conversely, reductions in INR/PT have also been reported in chronic alcoholics with liver disease.

I recently had blood work done and my liver enzymes were both 45. The doctor is not concerned. Should I be? Apparently the normal number is 35. I am 73 and take Warfarin for atrial fibrillation. I also had a hip fracture nine months ago. I also take a blood pressure medication, Diovan, and Metopropolol 25 mg. Would any of these drugs cause the elevation in liver enzymes?

I have had normal liver enzyme test and a normal ultrasound and ct scan, but I still have extreme bloating. This has been going on for months now. I worry because I binge drank on a nightly basis for about an 8 year span, 3-5(sometimes more) glasses of wine and such. Should I be worried that I have liver damage that is just not showing up? I have changed my diet significantly ( no dairy or gluten) but I am still very bloated. I am sick with worry that I have caused permanent damage.

The only way to truly ease your mind is by being totally honest with him/her. I have liver damage and kidney damage due to drugs stage 2 liver stage 3 kidney.. if your liver were damaged and you had a flare your belly would be extended/pain upper right you would be lethargic/vomiting.. other symptoms but these being severe.. It is not fun and I would not wish it on anyone.. I contracted hep C from slamming and further continued the damage through pills/alcohol..

I have never been to hospital, I dont appear to have yellowing of the skin or eyes. What is the likly hood of damage to my liver, and if stoped now could my liver possibly recover from and damege.

My brother has been in the hospital for 12 days for liver damage. His skin and eyes are yellow, abdomen pain and swelling of the stomach. They drained off 12 liters of fluid from stomach area. He's has dementia, no communicating with him that makes any sense. In this situation what is his chance to make it through this? The doctors and nurses are not saying much, but wait and see.

Are these symptom of HB - I have to be at the Oncology Department on Tuesday to have an ultrasound done of the abdoman - seem to get frequent bladder infections and my liver reading indicated high level of anitbodies. I have drunk alcohol and do not smoke either. I have hypothyroidism but Dr made my Thyroxin and Armour intake too high per day - was on 125 mg Armour and 0.1mg of Thyroxin now cut to 50 Thyroxin and 40 Armour Thyroid. Could this impact on my liver?

Warfarin and liver damage

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