Warfarin and liver damage

Common Questions and Answers about Warfarin and liver damage

jantoven

Steve, Thanks a million for posting this link for others. Just had a friend undergo a liver & kidney transplant last week and I'm going to share this link & information with her Surgeon. Any more information you know about would be greatly appreciated. Do most patients that develop cirrhosis of the liver due to drinking, end up getting Hep C? If so, can you explain why?
However, over the years, I've run many of these tests and have found that 2 to 3 tablespoonfuls of cod liver oil daily were always enough -- and not too much -- to do the job. Remember: Whenever you take supplemental oils or essential fatty acids, always take extra vitamin E, as mixed tocopherols, to prevent the oils from oxidizing too rapidly in your body. Take 800-1,000 IU of vitamin E with 2 to 3 tablespoons of cod liver oil each day.
The researchers hope that treating these patients with warfarin will prevent this liver damage and improve their prognosis. Transplant patients have a liver biopsy every year following transplantation to assess their progress, and the researchers will analyse data from this biopsy to establish the effectiveness of the warfarin treatment.
The serum albumin concentration is usually normal in chronic liver diseases until cirrhosis and significant liver damage is present. Albumin levels can be low in conditions other than liver diseases including malnutrition, some kidney diseases and other rarer conditions. Prothrombin time (PT): Many factors necessary for blood clotting are made in the liver. When liver function is severely abnormal, their synthesis and secretion into the blood is decreased.
All the drugs you mentioned might cause problems only if you are in end stage liver disease and very extensive liver damage is present. Your labs show that this is not the case. Even with extensive liver damage all these drugs still can be used, but the dosages would have to be lowered. Anesthesia and contrast also can be safely used in patients with liver disease. The liver is very resilient and really can take a lot. Wish you the best and hope for a good outcome of your surgery.
As we could see above on the copy of ultrasound, I do not see any scars, and damage liver tissue, anything weird, liver surface is smooth, and again this NP said "cirrhosis" and she even put in the file "cirrhosis" !!! Ps. the only thing I have no knoweldge that they might thinking about liver damage is about measuraments...
Either her liver decompensated because of the amount of damage that had already taken place before she quit drinking OR her liver decompensated because something else continues to damage her liver. Has she been vaccinated against Hep A and Hep B? Is it possible that she may have Hep C or HIV? She should be tested for both of those and vaccinated for Hep A and Hep B. Other possible causes of liver disease should be explored and ruled out as well.
I'm active and work all day but I may have some problems with IR someday and I think it will be due in part to the treatment drugs and degree of liver damage. I will deal with it when the time comes. Also, to suggest and low dose regiment of metformin after tx is ludicrous to me. I don't view that drug as something on could take beneficially in low doses unless they are diabetic. I've seen what it can do to someone first hand, low dose or not.
I really can't advise you on stopping medications, you should talk to your doctors about that one but niacin and verapamil can increase liver enzymes and are worth asking your doctor about. I hope this helps.
Although rare, cyanobacteria like Spirulina may contain toxins called microcystins, which accumulate in the liver and can potentially cause cancer or other liver diseases.
Hi I have stage 4 HCC out side the liver with hep C cirrous. I am 61 years old and feel mostly OK. My oncologist wants me to start taking nexavar, but she said that I could not spend time in the sun. Being a surfer and would like to take some time in MX. This drug does not sound to good for the amount of time (3.5 to 3 moths of life extension) that it boast will give me. has any one had any experience with nexavar and the sun?
He was developing severe tiredness and hand pain. He was investigated by cardiologist and was administered for Warfarin Sodium treatment; since the heart turned weak and one of the chamber was accumulating blood clot. He was regularly (initially weekly and then bi weekly and now monthly) tested for PT/INR response to the drug. But, on routine check up it is diagnosed that his SGPT and SGOT Levels have touched alarming.
I am about to do labs again. I'll post the results, but my labs have been improving since I started LDN and supplements about 11 months ago. Good energy and sleep through the night without waking.
But I still have the coronary artery disease and my cardiac blockages are from Plaque buildup. I am still trying to figure how why one trumps the other.
This causes inflammation and damage and it leads to autoimmune disorders. The cause of autoimmune diseases is unknown, but it appears that there is an inherited predisposition to develop autoimmune disease in many cases.
Sometimes high AST levels can signal that one of the medicines are causing liver damage. My step-father was on Lovastatin and his doctor tested his liver once a month. After several months, his ALT and AST levels were high, so they took him off the medicine. I would also stop drinking alcohol, and retest to see if that was the problem. Good luck!
It is not clear from your post the test that you had performed. I guess it is: Prothrombin time , and the ratio that you mentioned is the INR. From Wikipedia: "The prothrombin time (PT) and its derived measures of prothrombin ratio (PR) and international normalized ratio (INR) are measures of the extrinsic pathway of coagulation. This test is also called "ProTime INR" and "INR PT".
a ct scan in the er was the only thing that found it.....spent 6 days in hospital on morphine and warfarin, discharged on warfin and pain meds, but would like to know how long it is going to take till i feel better.......
After close to 15 years of warfarin I was exhibiting much the same symptoms as a stroke patient. Long term use of warfarin will damage and while it can be argued that being damaged is better than being dead, it is not as good as being alive and as undamaged as possible. I informed my cardiologist that I had stopped taking warfarin, wrote down what I was taking instead and a year later asked him if he had looked up nattokinase to see what it was, and he hadn't.
Just to note, the side effects associated with warfarin (such as coumadin) blood thinners are numerous and well documented. They include haemorrhage - internal bleeding, abdominal pain and cramping, diarrhea, fatigue and lethargy, feeling cold and chills, liver damage, loss of hair, nausea. While you may want to stay on this drug for the year, the side effects are offputting to say the least. There is an alternative called nattokinase.
You need to avoid foods and drugs that are also blood thinners such as asprin, advil, NSAIDs, Aleve, Orudis, and other pain killers. Only take what your doctor suggests for you to take for pain and nothing else. You need to reduce Vitamin K because it interveres with the absorbtion of Coumadin. Don't eat leafy greens like broccoli, cabbage, brussel sprouts, or spinich, etc. Don't eat liver or other organ meats. Don't take vitamins or herbal supplements without telling your doctor.
EXPLANATION OF TEST RESULT This is the most important test to follow in a person with liver disease. A high ALT may mean a high degree of liver cell damage. However, ALT levels can also vary, and do not always reflect the degree of liver cell damage. A liver cell biopsy will give the most accurate information. The ALT enzyme is a more accurate marker of liver damage than the Ast enzyme. One goal of treatment for hepatitis C is a normal ALT level.
In a conflicting report, the effects of acute and chronic dosing of APAP on warfarin pharmacokinetics and pharmacodynamics was studied in 20 healthy males in a 2-phase, randomized, crossover study. The mean serum concentrations of S- and R-warfarin did not differ significantly between treatments. There was no change in anticoagulation response between treatment and control (4). INR should be monitored more closely when APAP use exceeds 2 g/day or chronic use > 7 days occurs. References: 1.
However, ALT levels can also vary, and do not always reflect the degree of liver cell damage. A liver cell biopsy will give the most accurate information. The ALT enzyme is a more accurate marker of liver damage than the Ast enzyme. One goal of treatment for hepatitis C is a normal ALT level. NAME Antibody DEFINITION This is a protein developed by your body that protects you from an antigen.
I have been suffering severe anxiety due to a deep vein thrombosis and pulmonary emboli from the end of January. I am on warfarin tablets. My anxiety is worse after physical symptoms; such as pain and discomfort in both legs. Does anyone out there on warfarin have these or similar discomforts and how do you overcome the anxiety?
They are used to determine the clotting tendency of blood, in the measure of warfarin dosage, liver damage, and vitamin K status. PT measures factors I, II, V, VII, and X. It is used in conjunction with the activated partial thromboplastin time (aPTT) which measures the intrinsic pathway. The reference range for prothrombin time is usually around 11–16 seconds; the normal range for the INR is 0.8–1.2. Clinicians desiring therapeutic anticoagulation may aim for a higher INR - in many cases 2.
thanks to the OP for posting those possible causes etc as I now think it may be allergy, Iam taking a LOT of herbal supplements for my Liver Disease and I think it may be related and the ringing is like a 'pressure build up' sort of noise - the humming must also be part of it, so Im gunna stop all my supplements which include Milk Thistle, Multi-Vitamins, Cod-Liver Oil, Dandelion , Artichoke and Herbal Teas (although most of those have just started recently) if any I think it be Milk Thistle a
I quit taking St John Wart when it didn't help with the depression, I am now convinced was caused by long term use of diuretics and not keeping my minerals balanced, and not getting my protime taken and getting my warfarin adjusted put me in the hospital with warfarin poisoning. I am extremly lucky I didn't bleed out. When I was admitted to the ER, SOP is to put in a stent. Blood squirted from my arm and went all over the wall. Then I knew why it felt like an elephant was sitting on my chest.
You can have great liver enzymes and still have liver damage going on you know. Have you ever been biopsied? It's nice to want to "keep your body virginal" however your liver is not quite in that state. Interferon isn't all that whacky a drug our bodies DO produce it and with treatment our immune systems are taught how to use it effectively to ramp up and kill the virus.
I know about aspirin and I don't take it either. Coumadin will destroy soft tissue. I suffered memory loss, had my gums destryed and suffered liver damage. As far as I can tell it was not necessary. People who are put on this drug need to be very aware of the dangers involved in using it, only use it if it is the only course and only use it for the minimum amount of time possible. It took over a year for me to recover the ability to speak correctly again.
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