Warfarin and grapefruit juice
Common Questions and Answers about Warfarin and grapefruit juice
jantoven
So, I just poured myself a glass of grapefruit juice and took my medicine - then for some reason I remembered that grapefruit juice interacts with some medications. I just did a quick search online and here is a list (probably not complete) of some medications that interact badly with grapefruit juice. Including some opiates.... Please be careful!
a small part of the piece I read:
"Amy Karch, R.N., M.S.
Metoprolol is inhibited by the CYP 2D6 enzyme, which is inhibited by many other medications (among others most SSRIs, except Zoloft)
The danger with grapefruit and especially grapefruit juice (as you can easily drink juice equal to 6-7 grapefruits) is the combination with antiarrhythmics causing a prolonged QT interval, which have very narrow therapeutical windows (low difference between dosage and overdosage) or other substances prolonging the QT interval (certain antibiotics, etc.
One group took the antihistamine with grapefruit juice; another with water laced with naringin, the substance that makes grapefruit juice taste bitter; and the third group took the antihistamine with just water.
Analysis revealed that the grapefruit juice hindered absorption by as much as half over the group taking the medication with water alone. The difference is said to be enough to generate a critical difference in the treatment of many serious medical problems.
It is interesting that twopack mentions 'Supplementing with cranberry juice' , following my husbands triple bypass he was advised not to drink cranberry juice; also no grapefruit or grapefruit juice can be taken with some of his heart tablets.
You should be eating greens it's important to be consistent in the amount you eat so the warfarin level could be constant.
, itraconazole), clarithromycin, nefazodone, diltiazem, verapamil, protease inhibitors (e.g., indinavir).
Do not eat grapefruit or drink grapefruit juice unless your doctor instructs you otherwise. Do not start or stop any medicine without doctor or pharmacist approval.
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Here's info on "Statin" drugs (Zocor is a statin drug). This came from:
http://promini.medscape.com/drugdb/general_drug_adverse_effects.asp?
Dear gosburn,
More important than avoiding all vegetables is to eat a diet that has similar amounts of vit. K. Also you should avoid grapefruit juice as this ca affect you INR levels. I would avoid the supplments and focus on a balanced diet. A dietician may be able to help you regulate things better. There is a home kit and I would recommend it if you can afford it. Generic is OK as long as you always get the same generic brand. Otherwise brand name is better.
Dear Robert,
It is possible for jumps in the INR to occur and this is why careful monitoring is important. Atenolol may interact with coumadin (generic warfarin). Common foods such as grapefruit juice, leafy green vegetables and many drugs can also change coumadin levels. Smoking also changes drug levels.
The following is information on warfarin and it's drug interactions.
Coumadin (generic name Warfarin) is a anticoagulant (blood thinner) that is used for a variety of conditions.
There are many drugs that interact with coumadin (see below). Common foods such as grapefruit juice, leafy green vegetables and many drugs can change coumadin levels. Smoking also changes drug levels. Also be sure to take the same brand of drug each time and always take the drug at the same time of day (usually 6pm).
The following is information on warfarin and it's drug interactions.
There are many drugs that interact with coumadin (see below). Common foods such as grapefruit juice, leafy green vegetables and many drugs can change coumadin levels. Smoking also changes drug levels. Also be sure to take the same brand of drug each time and always take the drug at the same time of day (usually 6pm).
The following is information on warfarin and it's drug interactions.
There are many drugs that interact with coumadin (see below). Common foods such as grapefruit juice, leafy green vegetables and many drugs can change coumadin levels. Smoking also changes drug levels. Also be sure to take the same brand of drug each time and always take the drug at the same time of day (usually 6pm).
The following is information on warfarin and it's drug interactions.
Curcumin, Quercetin, Hesperidin, Ellagic acid, Resveratrol, Vitamin E and vitamin C combination.
Do you know: anything about this? Thank-you for your information.
: :
: : : : I will let an MD answer your questions, but my dad has been on Coumadin for 4 years without any problems whatsoever. In fact, his physician says he's the best patient he's ever had as far as controlling his Pro Time level. Don't be afraid of the coumadin, just be careful with it. My dad does anything he wants to, just watches what he eats so he gets no interactions with food.
between diabetes and watching blood sugar levels, and taking the blood thinner warfarin because of the a-fib, and a statin ( no grapefruit). For every yay, there's a nay. I was wondering if anyone out there feels like the palps build up over a few days and then they break into an episode of a-fib or some other equally aggraving arrhythmia? After my a-fib is over I feel free for several days, really goood, till the whole cycle starts all over again. Does anyone else sense that?
Never take any medications or vitamins or herbs with grapefruit juice or antacids. Grapefruit juice can litterally incrase the strength of medications. Antacids can render them ineffective. Its not enough to hear or see natural. You have to know what your taking and how, when and what to take them. READ YOUR LABELS! DO NOT DOUBLE OR TRIPLE ANY VITAMIN, MINERAL OR HERBS! Normally a good quality food based multivitamin/mineral supplement is sufficient.
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