The most common side effects include enlargement or tenderness of the breasts (both sexes), swelling of the ankles and legs, loss of appetite, weight changes, retention of water, nausea, vomiting
, abdominal cramps, and
feeling of bloatedness. The estrogen patch can cause skin rash, irritation, and redness at the patch site.
Less common side effects are bleeding gums, breakthrough vaginal bleeding, vaginal spotting, changes in menstrual flow, painful menstruation.