Many studies say there is no difference in kidney function change between
Viread and Entecavir. You have to remember, many studies of
Viread come from HIV, where they take many medications at once which all puts a strain on kidneys.
My opinion and if I were you, I would take an antiviral due to your increased viral load (above 2,000 iu/ml hbeag negative), Genotype C, mutations which have increased risk of HCC, and family history of HCC.