Withdrawal is awful and even the gradual phasing off of it can be intensely difficult. I do know that it has
side effects in some individuals which can be problematic (elevated blood pressure, increased sweating, etc.), but I have not personally experienced those symptoms. The blessing of Effexor XR for me, personally, has been immense. Though there are other, newer NSRIs on the market (Cymbalta is one of those), Effexor is the ONLY one that has ever worked for me.