TRAMADOL (in Ultram) may interact with VENLAFAXINE HYDROCHLORIDE (in Effexor)
Both
venlafaxine and tramadol have an effect on
serotonin, a chemical that is found in the brain. Excess levels of serotonin in the brain may cause serious or potentially life-threatening side effects. Early signs of this problem include increased confusion and restlessness. Other possible symptoms may include weakness, fever, nausea, and anxiety.