It can be due to several causes like muscle fatigue, muscle cramps, injuries, inflammation, varicose <span style = 'background-color: #dae8f4'>vein</span>s
, neurological causes like peripheral neuropathy / sciatica, dehydration, atherosclerosis, arthritis, gout, depletion of minerals like potassium or sodium, medications such as diuretics / statins, bone tumours and
several other conditions.
You should consult a doctor for a complete evaluation. Various investigations can be blood workup, arteriogram, bone scan, X-ray / MRI / ultrasound.