Valsartan and losartan

Common Questions and Answers about Valsartan and losartan

diovan

I've been taking 40mg/day Diovan/valsartan recently in addition to beta blockers. I've heard about studies and reports that ARBs such as losartan and valsartan have proven effective in mice to treat aortic aneurysms in Marfan mice and to effectivel 'heal' them. 1.) So this is a general question - in your practice, have you seen beneficial results on human aortic aneurysms using ARBs? 2.
It is thought that losartan is not as good a choice as other ARBs like valsartan and telmisartan because losartan penetrates tissue less than those drugs and because losartan is a surmountable antagonist that could, theoretically, lose effectiveness over time. This isn't a proven fact to my knowledge and Dr. Dietz for various reasons may or may not agree.
"THe above information about valsartan and losartan seems contrary to the literature describing size as irreversible. Daily variations in measurements may occur, but actual shrinkage seems out of the question, according to what I have read. I am very curious if any further study on rats or otherwise has shown shrinkage. " Your information is outdated. ARB therapy results in ACTUAL shrinkage, not mere variation.
So I would like to know if a dosage of around 25 mg of atenenol, (I take atenenol because I'm a very active person), and a high one of losartan would be a bad combination of the two drugs. Also what is the difference of losartan and valsartan?
I've been on an ACE but switching to Losartan 50mg and will request to go to 100mg based on what I've read. I will be getting a second opinion due to the wide swing in readings two days apart and just to get another prospective. My doc was oblivious to any Losartan studies. Would my theory on inflammation be wishful thinking?
My new VA doctor wants to change one of my blood pressure medications from 160 mg of Valsartan 2 times per day to an equivalent dose of 100 mg of Losartan but only once per day. My blood pressure has been controlled for years with typical readings around 118/70 using the Valsartan, Amlodipine 5mg, and a diuretic (hydrochlorothiazide 25mg). I have not made the change yet. 1. Why should I agree to experiment with reducing my primary blood pressure medication and what are the risks?
As you may be aware, there has been enormous excitement in the Marfan community lately based on research originating at Johns Hopkins using ARBs (and in some studies, ACEi's) like losartan to reduce TGF-b signalling and thus arresting or even reversing aortic dilatation.
I have COPD and something was aggravating my breathing problems. I went to the doctor yesterday and he took me off the Metoprolol and put me on 100 mg of Losartan. He told me to just stop taking the Metoprolol. I questioned starting off with such a high dose of Losartan. I seem to be very sensitive to these medications and felt starting right off with 100 mg was a bit high. Everything I've read online suggests people are usually started off with 50 mg.
Actually, is Diovan belongs to a class of blood pressure medications called angiotensin II receptor antagonist. It is a combination of Valsartan and the same diuretic as Hyzaar. It is essentially the same as Hyzaar which contains a combination of hydrochlorothiazide and losartan. Hydrochlorothiazide is a thiazide diuretic (water pill) that helps prevent your body from absorbing too much salt, which can cause fluid retention.
Personally, I take valsartan, but my friends have experienced similar success (or better) with candesartan, telmisartan, losartan (although this drug is surmountable and thus theoretically not the best one to take), irbesartan, and, for ACE inhibitors, perindopril.
Research reports favour different ones and contradict each other. Some favour Candesartan, others Losartan; and still others Valsartan. They all have slightly different modes of action. Which would you choose? OR - would you favour a different class of BP meds? CNS; vasodilators; calcium channel blockers etc. Since I had a problem with ACE inhibitor, would I also have a problem with ARBs, given that their modes of action is similar?
Some medications for high blood pressure include captopril (Capoten), enalapril (Vasotec), losartan (Cozaar), valsartan (Diovan), diltiazem (Cardizem), Amlodipine (Norvasc), hydrochlorothiazide (HydroDiuril), furosemide (Lasix), and many others. • Warfarin (Coumadin) interacts with COENZYME Q-10 Warfarin (Coumadin) is used to slow blood clotting. Coenzyme Q-10 might help the blood clot. By helping the blood clot, coenzyme Q-10 might decrease the effectiveness of warfarin (Coumadin).
I have tried Losartan for 3 weeks and yesteday the doc changed it onto Valsartan.
THIS is the problem with most cardiologists today. They routinely prescribe beta blockers for patients with aortic root dilatation, even though the most recent studies have shown that they DO NOT HELP YOU. Beta blockers are prescribed because they make sense on paper, but in practice, they are absolutely useless. These doctors are also grossly behind the times. I don't know whether they are ignorant of the latest, big-news breakthroughs or just unwilling to try them.
Marfan Syndrome Interventions: Drug: Losartan and nebivolol; Drug: Losartan; Drug: Nebivolol 3 Recruiting Randomized, Double-blind Study for the Evaluation of the Effect of Losartan Versus Placebo on Aortic Root Dilatation in Patients With Marfan Syndrome Under Treatment With Beta-blockers Condition: Marfan Syndrome Interventions: Drug: Losartan; Drug: Placebo 4 Recruiting A Randomized, Open-label, LOSARTAN Therapy on the Progression of Aortic Root Dilation in Patients With
Some other ARBs and ACE inhibitors may work less effectively or not at all (some ARBs I know to be good - besides telmisartan - are valsartan, irbesartan, candesartan. Most of them are good EXCEPT for losartan, which is a surmountable antagonist and, theoretically, would lose its effect over time). Next fact: you need to take a high dose.
Candesartan - Atacand Irbesartan - Avapro Losartan - Cozaar Telmisartan - Micardis Valsartan - Diovan Other, Less Commonly Used Hypertension Drugs Clonidine - Catapres Doxazosin - Cardura Guanabenz - Wytensin Guanfacine - Tenex Hydralazine hydrochloride - Apresoline Methyldopa - Aldomet Prazosin - Minipress Reserpine - Serpasil Terazosin - Hytrin Combination Drugs For Hypertension Amiloride and hydrochlorothiazide - Moduretic
angiotensin II receptor antagonists such as candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), losartan (Cozaar), olmesartan (Benicar), telmisartan (Micardis), and valsartan (Diovan); antacids such as sodium bicarbonate; caffeine (found in certain medications to treat drowsiness and headaches); calcium channel blockers such as amlodipine (Norvasc), diltiazem (Cardizem, Dilacor, Tiazac, others), felodipine (Plendil), isradipine (DynaCirc), nicardipine (Cardene), nifedipine (Adalat,
valsartan (Diovan), olmesartan (Benicar), candesartan (Atacand), losartan (Cozaar) • Angiotensin converting enzyme (ACE) inhibitors: enalapril (Vasotec), captopril (Capoten), benazepril (Lotensin), fosinopril (Monopril) Some substances may decrease the amounts of lithium in the body, examples include: • Caffeine CAFFEINE • Theo–Dur®, Slo–Bid® (theophylline) http://www.nami.org/Content/ContentGroups/Helpline1/Lithium.
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A beta blocker like, atenolol or toprol, and a ARB, like cozaar(losartan)or Diovan(valsartan), a mild durectic like Esidrex(hydrochlorothiazide) all combined might be useful, just a suggestion, get her to ask her doctor about these drugs, they could probably get her B/P under control. Hope you are okay. Take care. Took your advice also.
candesartan (Atacand), eprosartan (Teveten), irbesartan (Avapro), telmisartan (Micardis), valsartan (Diovan), losartan (Cozaar), and olmesartan (Benicar). ARBs are used for controlling high blood pressure, treating heart failure, and preventing kidney failure in people with diabetes or high blood pressure. They may also prevent diabetes and reduce the risk of stroke in patients with high blood pressure and an enlarged heart. ARBs may also prevent the recurrence of atrial fibrillation.
I am on Atenolol...and a healthy dose...50 mg in the morning..and 50 mg at night. I have read posts here where people really have trouble with it, but I just love it. It keeps my heartrate down---and (most...well...some..) of the time it helps with the palpitations. I had some dizziness when I first started taking it, but thats it. Not one other side effect. I was also on Lipitor a year ago...It really worked, and I had zero side effects from that. Hope this helps!
But I remember that you mentioned your doctor prscribing some ARB medication (losartan or valsartan) to halt liver fibrosis. This could be an important factor in your results. I wonder if there is any chance that you do not have cirrhosis. After my husband's experience with "golden standard" nothing would surprize me, and I sincerely wish this for you. What if during biopsy they just picked the piece that had a lot of damage?
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