They cover the outer half of both lips, top and bottom). I've tried acyclovir and generic
valtrex, with no relief. Not even a two hour break. Still taking generic valtrex (1 gram twice a day). I am taking Thompson's lip relief (lysine, vit c, zinc, bioflavanoids) and an immune support (andrographis,olive leaf, echinacea), and have been for a few weeks. I apply Super Lysine and lemon balm cream. I cut out caffeine (ouch!