tysabri test

The screening test for the JC Virus for patients considering Tysabri as their tretment was officially approved by the FDA today. The test tells if the person has been exposed to the JC Virus or not. PML on tysabri has only occured in people who are JC positive. There has not been a single case of PML in JC negative people. You can read the release here- http://www.medpagetoday.

the big rush we get at ECTRIMS time with all these new thoughts and projects is always a thrill to me. I'm skimming through the releases, abstracts and poster presentations and finding lots of good stuff. I didn't see the correlation of the test between Tysabri and Tecfidera efficacy and will have to go back and read it in detail. I say we all go to ECTRIMS next year when it is in Boston....

HOWEVER if you continue to test negative for the JC Virus there is no reason you should have to stop tysabri if it is working for you. In fact, stopping Tysabri is shown to cause serious relapses and is not something fun to go through. I would talke to a different doctor about tysabri and get off the holiday idea. Of course if you test positive for the JC virus, that is a different story entirely. good luck in working this through with your medical provider.

There is an alogirthm for the chances of contracting PML while on tysabri. I believe it is on the tysabri website among other places. I will see if I can find it for you and report back.

In the time I have been taking Tysabri, they have obtained much more data, as more and more people began taking Tysabri and staying on it longer. The JC virus test has been very helpful, allowing people who are negative to go on Tysabri with much less worry of PML, as well as giving people who test positive a better idea of the risks and allowing them to make more informed choices and decisions. At this time, they have identified 3 main risk factors for PML while on Tysabri: 1.

I am one of the older posters, and I am still on Tysabri. I just had #32. I had the JC virus test but still haven't gotten my results. Overall, my neuro and I both feel that Tysabri has helped slow down the parade of symptoms I was having, and that I'd be alot worse off right now if I wasn't on it. Feel free to PM me if you have any questions. ....

My new neuro suggested Tysabri based on increased lesions on Interferon (Rebif). Any persons out there on Tysabri that could share their experience?

I had blood work done about 1 week before infusion #4 and found out last week that my tysabri antibodies test came back positive. Going tomorrow to see the dr for next step. Anyone have this experience of developing antibodies so quickly? What meds have been offered after tysabri?

Good luck with Tysabri! I'm taking my 11th infusion on Wednesday. The good news, I haven't had any new flairs since I've been on it. I'm taking a "holiday" from Tysabri after this infusion. My neuro says a periodic holiday keeps the incidence of PML lower. I haven't had my JC virus antibody tested. Is this a blood test, or a urine test?

t feel like it did anything for me. I would like to go back on Tysabri. My test level is actually very low. Do you know how high the JC Virus level has to go to be high risk for PML to set in?

Could you give us a little background on what meds you've tried and for how long? I'm sure you've mentioned it before but I have a hard time keeping track of so much.

relapse/flair, whatever. It was 9 days of no fun. They even refused my Tysabri last week because I had a fever of 99.0. Am still on antibiotics for a UTI that I didn't know I had, which I think was really cystitis. Anyway, I have 3 more days of Ciptro and Tysabri is tomorrow. Will make sure I take aspirin to keep any fever down. I've been 6 weeks off Tysabri now.

I was offered Gilenya when I had problems with Tysabri (which turned out to be something other than Tysabri that caused it) and after reading the cardiac warnings and other side effects, chose not to take it. Tysabri has a wonderful financial support program. They fully donated my first 4 months of Tysabri until I could get an insurance program in place. Tysabri is considered an "outpatient" procedure and under my insurance, is paid for now at 100%.

Glad your Tysabri went well. Not so glad on no sleep! Let's hope that is a one night stand! Good for you!

Over the last 12 years he has been on all the ABC drugs. Now he is completing the 2 year mark of using Tysabri. Dr Appointment in 2 weeks assume he will stop infusions. I wonder what is next???? How are others doing after all these treatment and now what do they take???

Hi everybody! I've been away in Nevada and Arizona in 110+ temperatures for the last two weeks and for the first time ever felt the effects of heat. now back in greater Toronto area and they're calling for it to be the hottest week so far this summer! Anyway, I wanted to give you all the update on the drug decision. I decided to go on Tysabri but now can't because the JC test came back positive and the titre test came back too high so the neuro advised against Tysabri now.

So now he wants to take me off of the Copaxone, I have been on for a month and a half, and put me on Tysabri. I started the application process and now waiting for them to call me and get the ball rolling on that. Now he mentioned that this is the top of the line MS medication so that does give me some relief. P.S. I did test negetive for the JC Virus. Any thoughts, experiences etc on this Tysabri??!!

Has anyone ever had an occasional "off" day with Tysabri? I went for my infusion yesterday and usually they don't bother me at all but spent the rest of the day on the couch, with no energy and all day today with none. Can't remember having one like this in quite awhile and just wondering if anyone else had this occasional problem. Most of the time, its just like I got a saline injection!

m still OK Tysabri wise speaking. My neuro likes to reevaluate Tysabri use at 24 months. I had infusion # 18 last week. He thinks I would be an excellent candidate for Tecfidera. He said that if DMD'd were ranked from 1-100, in terms of 'power' Tysabri would be 100 and Tecfidera would be 75/80. As my MS seems to be pretty well under control. I may have needed Tysabri to get it under control. but Tecfidera should be able to keep it under control.

The Risk of PML is greatest in the setting of a positive J-lymphocytesC virus, greater than 24 months of Tysabri, and concurrent use of other DMD's or steroids. Those are old recommendations, and new info will change them in the (near?) future. PML is caused by the J-C Virus. A little more than half of all people have been infected with the JC virus. It generally lives asymptomatically in the brain unless something has occurred to cause the immunity of the brain to be compromised.

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