tysabri safety

My neurologist made me stop the Tysabri after 24 infusions because of safety concerns. I felt my overall best while on Tysabri and have asked him if and when I might be able to go back on the monthly infusions. He does not have an answer for me at this point. Has anyone out there ever gone back on Tysabri after taking a "holiday" from it in order to clear your body?

Hard to answer your question without more information. Why do you have only those four choices? Avonex (which I’ve used for 11 years) and others are notably absent from your list. Avonex, Rebif, and Betaseron have been around longest and have the strongest safety profiles. If your MS is more aggressive, then you may be more inclined to consider Gilenya, Tecfidera, Aubagio, or Tysabri. All of the DMDs are discussed from a neutral perspective at the link below: http://www.nationalmssociety.

I had been on Tysabri for 22 month's and just recently stopped. I was wondering if any new info. is out there on the drug Rituxan for MS? I have SPMS with RRMS. I was in a study 3 yrs. ago at UCSF and did really well on Rituxan. However, Rituxan is not an approved drug for MS and at that time my insurance would not cover it so I had to discontinue taking it. Or should I just take a break for awhile and not take any ms med"s?

It involves only one patient so far, and that patient is still alive. Despite ahving not used tysabri, they had used an interferon just before Gilenya, and steroids both before and during the Gilenya treatme t. Worth keeping an eye on this story, for sure.

If your illness is progressing rapidly Tysabri is an option. The others are equal in safety and effectiveness. It just depends on the injection method and frequency as to what you and your Doctor decide. Most Doctors let you decide. I took Copaxone for a year and side effects were not bad. The injections stung for a bit afterward but it was tolerable. I had no other issues. I suffer from Depression so choosing was easy since all the others can worsen depression. Good Luck to you.

I have never heard of a brain infection related to Gilenya … perhaps the doctor was referring to Tysabri, although a doctor should know the difference. Tysabri also may be worth a try. Yes, it has shortcomings, but like Gilenya, many people tolerate it well and have good results. I don’t know anything about gabapentin, other than that it is not a disease-modifying drug interchangable with Gilenya, Tysabri, Copaxone, Avonex, Rebif, and Betaseron.

Hi Ellador, I just completed my 41st Tysabri infusion the day before Thanksgiving. For me, since restarting the medication in October 2006, I have not had one single relapse nor any new lesions on my recent MRIs.

It would be interesting to see a head-to-head study with Tysabri, another monoclonal antibody... Of course Tysabri has it's own baggage. I wish they could come up with something that's not so potentially harmful.

And even if Tecfidera ultimately was directly connected to PML, know that Tysabri is too, and yet the vast majority of patients use it safely every month. It's something to be aware of, but no reason to throw out the Tecfidera yet. http://www.foxbusiness.

Here is what my neuro had to say about that, as many of you told me, many people who are JC+ take Tysabri. He explained that the TOUCH program allows them to monitor patients making it much safer. He did however tell me that I would be allowed to stay on Tysabri for only a year at best. Then he told me that although people feel great on it, as soon as they stop taking it they "crash and burn", meaning they feel terrible and begin having many relapses. Well that sure turned me off!

Food for thought for those on, or conteplating, Tysabri. Blood antibody testing for JCV may not be enough. http://www.medpagetoday.com/Neurology/MultipleSclerosis/39649?

m aware of who had a port implanted to receive Tysabri infusions. It was done when the monthly hunt-stick-miss-hunt again-stick again method of inserting a temporary line became too painful and burdensome to bear. I've never had a med-port but my sister had one placed for chemotherapy treatments - twice. She said the surgery itself was more uncomfortable than her (partial) mastectomy - not terrible, mostly just took her by surprise.

all the trial patients), and review all of the Safety Data so that they could resubmit Tysabri to the FDA for approval once again (Tysabri is only the second drug to be reapproved by the FDA). I was one of the MS patients that spoke before the FDA AC (via videotape) in March 2006 in an effort to bring Tysabri back to the market. I'm so very grateful that we all succeeded!

You might find this of interest- I have always wondered why we startt out wit hthe weakest drugs to treat our MS instead of going at it as agressively as possible - Biogen Idec and Elan Submit Applications for First-Line Use of TYSABRI in anti-JCV Antibody Negative Patients with MS http://tinyurl.

They found out the reason people contracted PML was because they were taking Avonex/and the other MS medications with Tysabri. I think the Tysabri has given me a second chance at helping slow my disease progress, but with out it I would be on no MS medications to slow the disease. I did alot of research before I decided to start the medication and the one resource that helped me make my decision was reading the Tysabri diaries on line. www.msrc.co.uk/index.cfm?

Are any of you on Tysabri? My doctor has suggested that I consider starting Tysabri treatment. His neurology practice runs a TOUCH infusion center. I've been on Copaxone for four years and have just had my first flareup. My recent MRI shows progression of MS with T2 hyperintense white matter lesions in the pons of the brainstem and the frontal lobe. Several of the older lesions have increased in size. Five years ago I was on Avonex. I had multiple flare-ups the whole year on this med.

I've been tested twice in the last year, and they were both negative. Since you can acquire JCV at any time, I opt to have my status tested once a year since I'm on Tysabri. There is also a Tysabri antibody titre available, now. I plan on doing that once a year, too, although development of Tysabri antibodies is relatively rare.

My new neuro suggested Tysabri based on increased lesions on Interferon (Rebif). Any persons out there on Tysabri that could share their experience?

This report is from the NASDAQ ******* business site - tracking key issues on the stock market - Biogen's stock fell Friday on heavy trading with the release of this news about their star drug ...... it is astonishing to think they make $1 BILLION dollars a year on this drug. - Lulu 4th UPDATE: EU Reviewing Biogen, Elan's Tysabri; Cites PML (Updates with FDA comments, beginning in the third paragraph.

Common Questions and Answers about Tysabri safety

tysabri