Tysabri pml multiple sclerosis

Common Questions and Answers about Tysabri pml multiple sclerosis

tysabri

Avatar n tn I have had RR multiple sclerosis since I was 10 ish diagnosed (finally) in 2008. Had routine MRi of head and neck last month, everything is stable for 2 years now. Thank you Tysabri! My question is the impression of my mri stated T1 and T2 disease burden is at least moderate ( written for head and cervical MRI). Also JCV negative this whole time can I stay on Tysabri indefintely as long as I am negative?
739070 tn?1338603402 Conclusions Positive status with respect to anti–JC virus antibodies, prior use of immunosuppressants, and increased duration of natalizumab treatment, alone or in combination, were associated with distinct levels of PML risk in natalizumab-treated patients with multiple sclerosis. (Funded by Biogen Idec and Elan Pharmaceuticals.) http://www.nejm.org/doi/full/10.1056/NEJMoa1107829?
572651 tn?1530999357 It occurs almost exclusively in people with severe immune deficiency, such as transplant patients on immunosuppressive medications,[1] patients receiving certain kinds of chemotherapy, patients receiving natalizumab (Tysabri)[2] for multiple sclerosis, psoriasis patients on long-term efalizumab (Raptiva)[3] or AIDS patients. It is caused by a virus, the JC virus, which is normally present and kept under control by the immune system.
147426 tn?1317265632 PHILADELPHIA, Pennsylvania — A new study shows that combining 2 markers for risk for progressive multifocal leukoencephalopathy (PML) during long-term therapy for relapsing-remitting multiple sclerosis (RRMS) with natalizumab (Tysabri, Biogen Idec) may expand the population of patients at risk compared with using the traditional single parameter of positivity for JC virus (JCV) antibody alone. "Patients that had high antibody titers had lower expression of CD62L.
294425 tn?1288528395 http://multiple-sclerosis-research.blogspot.com/2012/04/news-first-case-of-pml-on-fingolimod.
572651 tn?1530999357 ) By Thomas Gryta Of DOW JONES NEWSWIRES NEW YORK -(Dow Jones)- A European panel has started a review of the controversial Multiple Sclerosis drug Tysabri, sold by Biogen Idec Inc. (BIIB) and Elan Corp. PLC (ELN), citing a much higher number of rare brain infections than previously disclosed.
Avatar f tn We have a thread here with Tysabri patients discussing their experiences on it. Here is the link: http://www.medhelp.org/posts/Multiple-Sclerosis/Tysabri-Users---Past-and-Present/show/1569374?controller=posts&action=show&id=# If for some reason that doesn't work, just put in "Tysabri users past and present" in the search area at the top and you should find it. I go for my 40th infusion tomorrow. Feel free to PM me if there's any way I can help.
1088527 tn?1425313375 Hi Kat - I will get my 11th infusion in about 10 days. I have had no issues of any kind in conjunction with Tysabri. From the follow up MRI's I've had Tysabri seems to be doing the trick. No new lesions or relapses since I started. You will be tested for the JC virus prior to starting.
738075 tn?1330575844 • Although the absolute risk for PML in patients treated with Tysabri cannot be precisely determined, the U.S. FDA and the company have released data suggesting that the risk increases with increasing time on therapy. • The company changed the label of Tysabri to indicate that the risk of PML is increased in patients who have been treated with an immunosuppressant (such as mitoxantrone, and less commonly, azathioprine and methotrexate) prior to receiving Tysabri.
Avatar f tn Plasmorephis, blood filtering is already standard treatment to get Tysabri out of the body quickly if PML happens. I saw that a trial had been registered with the US FDA in clinicaltrials.gov when Tysabri was returned to market a trial was registered for Plasmorephis blood filtering to remove Trysabri from the body quickly whren it needed to be removed quickly. I was proud of myself for noticing when that trial was registed with the gov & watched it's successful completion.
198419 tn?1360242356 ve not seen the results of these studies (from MSAA site) *************************** Spring 2008 Research Update May 19, 2008 A one-year study in Germany found that 1157 patients with relapsing-remitting multiple sclerosis (RRMS) who began and continued on Avonex® for one year, benefited from nursing support. They also experienced a modest improvement in quality of life during this treatment period, as measured through the EuroQol questionnaire (EQ-5D).
198419 tn?1360242356 //www.medhelp.org/posts/Multiple-Sclerosis/Gilenya-Users-Past-and-Present/show/1469412 http://www.medhelp.org/posts/Multiple-Sclerosis/Copaxone-users---past-and-present/show/643683 http://www.medhelp.org/posts/Multiple-Sclerosis/Tysabri-Users---Past-and-Present/show/1569374 http://www.medhelp.org/posts/Multiple-Sclerosis/Aubagio-Users-Past-and-Present/show/1946899 http://www.medhelp.org/posts/Multiple-Sclerosis/Our-Tysabri-Users---Past-and-Present/show/658918 http://www.medhelp.
Avatar f tn "Genentech withdrew its psoriasis drug Raptiva from the market yesterday, citing the risk of developing progressive multifocal leukoencephalopathy (PML), a rare, often fatal brain infection. The drug will be phased out by June 8 of this year, according to a statement by the US Food and Drug Administration (FDA)." http://www.the-scientist.com/templates/trackable/display/blog.jsp?
294425 tn?1288528395 //www.medhelp.org/posts/Multiple-Sclerosis/Our-Tysabri-Users---Past-and-Present/show/658918.) We are hoping to have a source with more info, so that it can be easily referenced by anyone seeking insight into Tysabri. Here's some things we thought would be helpful for others to know: When dx'd? Other treatments prior to Tysabri? How long were you on them? How long have you been on Tysabri? Do you feel it is helping? Have you had any side effects?
216354 tn?1262871346 Last week when she went to the doctor, she was informed that patients who has been on the tysabri infustion for over two years have a greater chance of developing the brain infection PML. I believe she was told the odds went up to 1 in 800. However, she was also told that if she were to stop tysabri she was pretty much guaranteed to have an attack of the MS. She has an agressive form of MS and other medications don't seem to work.
Avatar f tn Just an update on PML, for anyone who is currently considering Tysabri, or who may need to look at it in the future...the original 3 cases of PML were indeed initially considered to be due to the use of Tysabri in conjunction with other treatments for MS, particularly interferon.
572651 tn?1530999357 The test tells if the person has been exposed to the JC Virus or not. PML on tysabri has only occured in people who are JC positive. There has not been a single case of PML in JC negative people. You can read the release here- http://www.medpagetoday.
Avatar m tn i had been diagonised with multiple sclerosis in the year 2001. now i am not able to walk. i am also not able to see clearly. my speech is also not clear. i think my type of ms is primary progressive since my condition has worsened gradually. pl suggest some medicines or other alternative therapy.