tysabri or natalizumab

If you put your questions into the search box above, or into the search archives box which is above all the latest posts, you will find the technical information on this drug and many many of the forum posts on the topic. Just type "what is Tysabri" or what ever you want to know and if its already been talked about it will come up :-) Cheers.....

Conclusions Positive status with respect to anti–JC virus antibodies, prior use of immunosuppressants, and increased duration of natalizumab treatment, alone or in combination, were associated with distinct levels of PML risk in natalizumab-treated patients with multiple sclerosis. (Funded by Biogen Idec and Elan Pharmaceuticals.) http://www.nejm.org/doi/full/10.1056/NEJMoa1107829?

t know numbers yet, as nurse wants Neuro to tell me) There was apparently a note on my file that if it was positive that I was not to go on Tysabri. We never discussed this with her, and if the numbers are high of course I would not try it. , but, I know of people who are positive and low numbers and have done very well on Tysabri. I just want o give it a shot. I have to wait now till Wed. when my neuro is in and the nurse will chat with her as to what to do.

Baseline Results of STRATIFY-2 – Platform S41.002 Long-Term Safety and Efficacy and Association Between Baseline Treatment History and Postbaseline Relapses in Multiple Sclerosis Patients Treated with Natalizumab in the TYSABRI Observational Program (TOP) – Poster P04.134 Natalizumab Reduces Fatigue as Measured by the Fatigue Scale for Motor and Cognitive Functions (FSMC) – First Results from the TYNERGY Trial – Poster P07.

The decision to start Tysabri can be a scarey one, whether we are JC postive or negative, there is something intimidating about starting a black-box drug. I know most of us here who are taking tysabri wrestled with these same questions and concerns.

Hi, guys. I wanted to talk briefly about what is being found out about the risk of PML. First I have to state that the current recommendations are still in effect. The Risk of PML is greatest in the setting of a positive J-lymphocytesC virus, greater than 24 months of Tysabri, and concurrent use of other DMD's or steroids. Those are old recommendations, and new info will change them in the (near?) future. PML is caused by the J-C Virus.

Food for thought for those on, or conteplating, Tysabri. Blood antibody testing for JCV may not be enough. http://www.medpagetoday.com/Neurology/MultipleSclerosis/39649?

It occurs almost exclusively in people with severe immune deficiency, such as transplant patients on immunosuppressive medications,[1] patients receiving certain kinds of chemotherapy, patients receiving natalizumab (Tysabri)[2] for multiple sclerosis, psoriasis patients on long-term efalizumab (Raptiva)[3] or AIDS patients. It is caused by a virus, the JC virus, which is normally present and kept under control by the immune system.

Then there are the monoclonal antibodies. Tysabri (natalizumab) is one of these. Rituxan and Campath, which is showing promising results for RRMS, are also being used.

- mild swallowing problems (it gonna be better to take steroids or not, and is it frequent symptom or not, who had simillar experiences, and is it gone or stay, stagnant or be worse) - double vision when you look right (gone, stay, stagnant or to be wore) - She would like to take a drug (first line drugs: avonex, rebif, betaseron, copaxone) Wich is the better chice?

//www.msra.org.au/new-reports-use-ms-medications-during-pregnancy Personally, with our family history of Autism I wouldn't be take anything, I wouldn't recommend anyone continue taking most types of medications (regardless of if it was a DMD or not) IF they actually have that choice though but i'm not you and not in your situation (!

Tysabri is a more potent drug that the initial ones many people are offered -such Rebif, Avonex, or Copaxone - and it sounds like your neurologist wants to treat your MS agressively. that is a good thing. I would have a talk with the doctor and ask all your questions, including what type of MS does he think you have. It would be highly unusual for someone with PPMS to be offered a disease modifying therapy because they haven't been proven to be effective for that form of MS.

In second line (if the first line treatment ineffective) she may chose tysabri (natalizumab) or gilenya (fingolimod). Fortunately RRMS'ers nowadays have a lot of effective treatments to fight against this desease. What is your current treatment, and what experienced? Good healt for you!

I would like some information/details from anyone who has had (or seen) the rash you can get from Tysabril and/or PML?? I have been on Tysabri 10 years so far without any major issues. I was outside after my treatment for 10 minutes or so. After taking my shirt off, my husband gasped and asked what was wrong with my back.

but nothing is impossible. If the palms of your hands begin to itch or you have any SOB or rapid heart rate.....seek medical attention. Hope everything is okay.

My son had been taking Tysabri for 3 1/2 years. During that time he’s had at least 3 blackouts where he has had very bizarre behavior but does not remember any of it. The neurologist said it wasn’t caused by the Tysabri, I disagree. This past June he went off of Tysabri and in August started taking the pill Tecfidera. Last week he had another blackout! Again the neurology office said it wasn’t the med that he should call his PCP. I really think it’s these medications causing the blackouts.

Tysabri or natalizumab

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tysabri