tysabri off label

s the official story. Many Tysabri users report a performance boost just after infusions and a drop off in performance just before the next infusion. I received 20 Tysabri infusions and didn't really feel much of either one. The good news was that I did not feel any obvious progression of my MS. Secondary Progressive MS is the eventual landing spot for 85% of people diagnosed with RRMS. I am among them.

One idea is Rituximab ( if my medical will accept off label). My doc has patieints on it, they are doing well on it. Who ouut there on foum has taken it?

Hi DH - Welcome to our group. I am currently getting Rituxan (rituxmab) and before this I was on Tysabri. They are the only two DMDs I've been on. I have had good experience with both meds. Tysabri lasted about 20 infusions before it stopped working. The Rituxan seems to be doing the job now. I started Rituxan in November of last year and finished my second round yesterday. I had no adverse reaction of any kind to either med.

This report is from the NASDAQ ******* business site - tracking key issues on the stock market - Biogen's stock fell Friday on heavy trading with the release of this news about their star drug ...... it is astonishing to think they make $1 BILLION dollars a year on this drug. - Lulu 4th UPDATE: EU Reviewing Biogen, Elan's Tysabri; Cites PML (Updates with FDA comments, beginning in the third paragraph.

For genotype 1 patients who cannot take interferon, the panel recommends sofosbuvir plus the HCV protease inhibitor simeprevir (Olysio), with or without ribavirin, again for 12 weeks. This off-label regimen has not been through full Phase 3 testing, but performed very well in the Phase 2 COSMOS trial.

Did your doctor prescribe it to you for this? If not, STOP right now...'experimenting' with prescription medications, which are extremely addictive can NEVER have good outcomes.

They all have reported feeling better daily - this off label approach is a God Send! Now I will finish out the 12 weeks - they will do the viral load test again at that time and then 12 weeks post treatment test again to declare me officially SVR!!! NO HORRIBLE INTERFERON OR RIBAVARIN THIS TIME FOR ME!!

Hi welcome to the Hepatitis C community Olysio per the prescribing information sheet is intended to be used with interferon and Ribavirin. The same applies to Sovaldi. Per prescription they are not used together. However there have been clinical trials using them together "off label" and they have been shown to be highly effective when used together. You can web search for Cosmos clinical trial cohort 1 and cohort 2 to see study results.

HI Candy, So sorry to hear of the new developments! I hope that your lipoma is just a lipoma. The bladder/vaginal wall surgery does NOT sound like fun. My sympathies and good wishes that all goes smoothly! As for status of SPMS, Tysabri has been known to help with stage per my neuro. Has it been considered? Remember that it's just a label and you are who you were before the label. Keep ightiing! You a strong one!!!

my doctor had me try an incontinence drug that was designed for men with enlarged prostates. Obviously that problem doesn't apply to me so my use was off-label. My insurance questioned it but eventually allowed me to try it (btw, it didn't help!). I'm wondering if dmd's could also be rx'd for PPMS patients? The thing is there is no proof that they would work. Sorry, but I am just thinking in words here ... this might make no sense at all.

m on a drug study, and Kyle above is on a next generation off-label treatment), so at least there are a lot of options if and when that time comes. Picking a treatment with MS can feel really complex, but it's doable! With information and knowing our own preferences, we and our neurologists hash it out.

Hi Kat - I will get my 11th infusion in about 10 days. I have had no issues of any kind in conjunction with Tysabri. From the follow up MRI's I've had Tysabri seems to be doing the trick. No new lesions or relapses since I started. You will be tested for the JC virus prior to starting.

t tell whats a flare, what is normal, and what is just my Tysabri wearing off. I can tell you this tho, if this is my norm after the Tysabri wears off, then it is definitely getting worse every month. My MRIs look good tho...NO CHANGES so gee I guess I am going great. I will be attending a candle light vigil for Marijane Lewis a 5 year old who was brutally murdered by her Mother this week. Please send your prayers for her. She was such a precious little girl born to the wrong parents.

Only Tysabri has shown the abilty to cut relapses and lesions by 2/3s. Tysabri is relatively new and is still has some issues. In fact no one knows what it does after 2 years. The more std. MS drugs, which are primarily interferons by the names of Avonex, Rebif and Betaseron cut MS activity by about 1/3. And thats if you have Relapsing Remitting MS. The drugs are all injected. A new drug that is oral "finglomod" is in phase 3 clinical trials.

Food for thought for those on, or conteplating, Tysabri. Blood antibody testing for JCV may not be enough. http://www.medpagetoday.com/Neurology/MultipleSclerosis/39649?

Hi MBHB - Having MS is not cheap! Even with pretty good insurance It can be very expensive. I'm on Rituan. MS is an off label use of rituxan, so most insurance won't pay. Mine does pay and my out of pocet for rituxan alone is close to $5,000/year! I'm hearing a lot of insurance company push back on the new dosing of Copaxone. Hopefully they will cover the old dose. It looks like Teva has some co-pay assistance programs, which I'm sure you've researched.

RITOXIN WILL BE AVAILABLE IN OUR AREA IN FEBUARY,THE CLINIC TRIALS ARE PROMISING. MANY IN ARE AREA ARE LOOKING FORWARD TO IT.

Dear Mrs Davies, I am really shocked that you could argue about any consideration concerning gender. A doctor cares about his patients regardless any particular or personal point either gender or religion or origin. You just CANNOT write and even think about that. I perfectly explained to you the importance of the new lesions in the spinal cord. These lesions are at high risk of developping paraplegia in the following months.

HI Rita, My friend on Tysabri that you spoke to always got frequent UTI's while on Tysabri, She went off the Tysabri six weeks ago since she was getting alot of new lesions on her spine and wanted to try LDN. Now that she is off the Tysabri, she is having pain for the first time with MS. She is not getting very good effects from the LDN and may end up back on Tysabri. I'll catch up with you later!!

Hi Kat- I stopped Tysabri following my 20th infusion, June 29 f this year. I have not been on any DMD since and have experienced absolutely zero rebound effect. I was going to stop because I converted to JCV +, but actually stopped because Tysabri didn't seem to be getting the job done. This took Tecfidera off the able, so I can't help there. I'm going to start Rituxan next Friday.

This past June he went off of Tysabri and in August started taking the pill Tecfidera. Last week he had another blackout! Again the neurology office said it wasn’t the med that he should call his PCP. I really think it’s these medications causing the blackouts.

I was on Rebif for 4-5 months before starting Tysabri. My neuro pulled me off the Tysabri for a "holiday". I'm on Betaseron in the interim... For the year I was on Tysabri, I had NO relapses! Good luck!

Tysabri off label

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