tysabri liver damage

I just started Rebif again this week on a very gradual titration schedule, and my liver will be monitored closely via weekly labs. If my liver enzymes elevate again, I will need to go off of it. My neuro has described my early MS as 'very active.' Last Sept, my MRI showed 1 brainstem lesion and 1 C-spine lesion. 8 months later my MRI still shows the same brainstem lesion; it does not show the previous C-spine lesion, but does show 3 new lesions on C-spine.

Hi all, My TOUCH center DOES monthly CBC, CD4 counts and liver function tests as a routine part of the Tysabri infusion experience. We see mid level practioners (MS Nurse Practioners) or the MD on a rotating basis so every 3 months I see the MD. Tysabri can cause liver dysfunction so they feel the testing is necessary to catch any developing trends. the CD4 counts and CBC they use to track treatment effectiveness.

Hey Guys, Just wanted to give you all a heads up, in the interest of us all being informed patients... :) I saw this article this morning, and here's the crux of it: "New Case of PML Confirmed in U.S. A new case of PML, or progressive multifocal leukoencephalopathy, has been confirmed in the U.S., in a patient receiving Tysabri for the treatment of MS. After 14 treatments, the patient reported a change in health status, and the patient’s physician began testing for PML.

Last week I started my 3rd significant relapse this year, my specialist nurse is now talking about Tysabri. I was on Rebif for about 15 months and wasnt getting on with the side effects so I switched to Copaxone 6 weeks ago, which I'm quite happy with. I looked up Tysabri when I got home and all I got was all the bad news about the PML patients. They say that theres a 1/1000 chance of getting it, that seems quite high to me.

Hey everyone went to my neuro today we are stopping tysabri due to liver enzymes elevated for last 3 months. Went to a GI specialist to rule any liver problems out and after all sorts of testing seems like tysabri is the likley cause. I will start tecfidera in 3 months I hope I dont have the rebound effect I have heard about after stopping tysabri. Tysabri has really changed the way I feel was using a walker now nothing and I do Zumba too. I hope I stay like this but having doubts.

Not to mention, that I will soon run out of good sites. I am a bit afraid of the Tysabri. Though she says there have 6 or so episodes of PML, some were Europe where they don't have the Touch program and pt are not followed as closely. She says 83% of users have no flairs in a 2 year study. She will see me monthly or sooner of course if necessary.

Didn't they just find something else as a side effect of Tysabri? Like a liver disorder or something?

Having said that, have you ever tried Copaxone? It has no flu like sx and no potential for liver damage so it has a lot of appeal! I hear lots about jab reactions but I had no pain whatsoever and no skin reactiions apart from immediate redness. Good luck!

I was on tysabri for 9 months till my liver decided it didnt like it anymore but I loved the drug went from using a cane to nothing. I just started gilenya yesterday so jury still out on that. Its been 7 months since being off therapy and feel like crap the fatigue is overwhelming and my balance is bad dragging foot again so should be using cane again just not mentally ready for it. if your jc neg I would go for the tysabri as long as insurance covers it 1 hr a month and done so easy.

The second thing is nerve damage which is progression. With nerve damage the symptoms are permanent. Doctors can't tell which is which except with time. For example I have had double vision for 50 years so that is nerve damage. Sometimes my legs do not work for a month or more then they go back that is inflammation. Most damage in MS is gray matter which does not show up on MRIs. MRIs are not worthless they back up what the doctor suspects. You can have symptoms to change on the MRI.

Will Tysabri help me if I can't walk very good at all? It's everyday all day,I think I have progressed from RRMS to Secondary progressive.

I am so scared I have caused damage to my liver. After I get off of these will it repair itself or am I in trouble. The only syntom I have right now is welling in my akiles and feet. But i have taken fluid pills for the fluid for yrs before I started taken lorcet.

s virus is still replicating if they have untreated hep c, but the amount of actual liver damage varies vastly from person to person, with some people being able to go years and years with more minimal damage and others progressing more quickly. To that end, I am wondering if you have had a recent liver biopsy and I'd suggest that as your next move (along with getting yourself to a very good hepatologist in your area - as opposed to just a gastro.

Well I saw my neuro today and after a lengthy discussion with both him and the nurse, the subject of UTI did not come up! There was so much else to cover, I completely forgot to ask and they apparently did too. Argh. Why didn't I write it down? No 12 year old resident this time lol so it was nice to get to know my neuro better. We had a long discussion about changing treatment.

I have failed rebif and my liver didnt tolerate tysabri after 10 infusions. I really didnt like the side effect profile from tecfidera and was hoping this was gonna get approved.

The recommended dose of paracetamol for a single adult is two standard 500 mg tablets. Researches have reported that the threshold for liver damage to start from a single paracetamol overdose is 15 gms (30 tablets). However liver damage could start to occur at a single overdose of 24 standard tablets or 150 mg/kg body weight, (whichever is the smaller).

(Former drug user) what are the chances I already have liver damage??? I go in the morning for a liver scan to check and I am nervous to know!!!

Is it possible to cause liver damage from a few years of pain med abuse? Damage severe enough to cause stomach pains?

I have been taking Darvocet for about two years now. I began just taking one a week at night after a bad day and it has progressed to 1-3 daily for about 6 months now. I went to the Dr. for a checkup yesterday and the ALT liver function test was high. The other liver tests were normal just that one was high. The Dr. thinks it is from my acid reflux medication and is changing that but I rarely take it. Could it be the Darvocet?

from the doc forum: http://www.medhelp.

Can anyone tell me what it's called when you have liver damage from medications

The only way to truly ease your mind is by being totally honest with him/her. I have liver damage and kidney damage due to drugs stage 2 liver stage 3 kidney.. if your liver were damaged and you had a flare your belly would be extended/pain upper right you would be lethargic/vomiting.. other symptoms but these being severe.. It is not fun and I would not wish it on anyone.. I contracted hep C from slamming and further continued the damage through pills/alcohol..

I have never been to hospital, I dont appear to have yellowing of the skin or eyes. What is the likly hood of damage to my liver, and if stoped now could my liver possibly recover from and damege.

Hard to say but if he stops attacking the liver with alcohol, no further damage should be done and some of those numbers should go down at least a little.

Tysabri liver damage

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