Tysabri july 2008

Common Questions and Answers about Tysabri july 2008

tysabri

Avatar m tn There have since been cases of PML as well as some deaths in patients who were taking only Tysabri at the time. When I started Tysabri in 2008, the estimated risk of PML was 1 in 1000. They knew being JC positive was a risk factor, but there was no test for it at the time. Most estimates I've seen are that approx. 50-60% of ALL people carry the JC virus, as it is actually very common.
198419 tn?1360242356 As of March 2008, more than 26,000 patients were on Tysabri® worldwide. Since the re-launch of Tysabri in July 2006, no new cases of progressive multifocal leukoencephalopathy (PML) have been reported. PML is an often-fatal viral infection of the brain. Data from the PLEX study suggest that plasma exchange may be an effective procedure for accelerating the removal of Tysabri from the blood if PML infection is suspected.
Avatar f tn Unfortunately, this proved not to be the case. At the end of July 2008, it was revealed that there were 2 new cases of PML in Europe - in people who were on Tysabri as their only treatment. In Europe, the program to oversee Tysabri is not as stringent as the TOUCH program is here in the US, and that may play into the scenario. There are a number of details that have yet to come out. One of the patients in Europe is recovering pretty well at this point, and one of them is doing very poorly.
Avatar f tn So now he wants to take me off of the Copaxone, I have been on for a month and a half, and put me on Tysabri. I started the application process and now waiting for them to call me and get the ball rolling on that. Now he mentioned that this is the top of the line MS medication so that does give me some relief. P.S. I did test negetive for the JC Virus. Any thoughts, experiences etc on this Tysabri??!!
Avatar n tn I had been on Tysabri for 22 month's and just recently stopped. I was wondering if any new info. is out there on the drug Rituxan for MS? I have SPMS with RRMS. I was in a study 3 yrs. ago at UCSF and did really well on Rituxan. However, Rituxan is not an approved drug for MS and at that time my insurance would not cover it so I had to discontinue taking it. Or should I just take a break for awhile and not take any ms med"s?
Avatar f tn He is comparing to a May 2009 done there but by a different reader. Oddly the last one he read on mine was May 2008. It is the May 2008 report where he specifies various dimensions of lesions. He describes them now as larger yet writes "unchanged." I know radios have a language all their own and their use of words is not the same as street English! The prescription just said MS.
Avatar n tn July 18, 2009 (40 weeks)
738075 tn?1330575844 My symptoms all magnified, and getting through a day of work was monumental. I guess it was all a matter of time before I flared. My last Tysabri infusion was on 11/2/13, and it took my new neuro and new infusion site two months to get their stuff together. The day before yesterday (1/8), I finally got a Tysabri infusion - Halleluiah!!! Hopefully, this flare will subside soon. I'm not one to go for IVSM unless I absolutely have to.
Avatar n tn 09 and I have since switched to Tysabri. With tysabri, all of my symptoms, (tingling, numbness, and pain) are all but gone. For me, Tysabri was more effective then Copaxone, but if you have MS and are thinking of switching, Tysabri is a very dangerous drug, inform yourself before making the decision.
Avatar f tn Hope everyone is well. I just wanted to give an update. I had my first Tysabri infusion this morning and I experienced no side effects so far at all. Over the last 2 months I have had some improvment. I still have all my symptoms but they're less intense. So here's hoping for the best. Hoping this medication works at seriously slowing this beast way down. How are things with everyone? I truly hope everyone has been well or well as can be expected.
572651 tn?1530999357 The company last reported 11 cases in July, when the company stopped providing weekly Tysabri update, and two more have been confirmed since then. The number of PML cases among Tysabri users is closely watched because the drug's label suggests an infection risk to one in every 1,000 patients. Tysabri was removed for 18 months beginning in 2005 because of a link to three other PML cases but was allowed back on the market after patients and physicians pushed for its return.
1831849 tn?1383228392 s as part of JCV/PML detection protocol. I am having a blood test, brain MRI and an LP every 6 months as part of my Tysabri treatment. This article from the Journal of Neurology discusses this protocol. http://www.msrcny.org/sites/default/files/articles/JCVpaper.
Avatar f tn My neuro is considering switching me from Rebif to either Tysabri or Novantrone. I started Rebif in Feb 2008, however was not on it long enough to really know if it was doing any good as far as disease progression/relapse reduction, as within 8 weeks my liver enzymes had elevated and my treatment was suspended. I just started Rebif again this week on a very gradual titration schedule, and my liver will be monitored closely via weekly labs.
Avatar f tn I'll be 60 this year and started Tysabri in January 2011. I continue to test JC negative and love having to do only one treatment per month. My MRI remains stable but I have had the slow, silent slide in symptoms that is discouraging. I believe i am on the best drug for me at this time.
Avatar f tn Hi. I'm new to MS and Tysabri. I was just diagnosed in July of this year. I basically had no symptoms. Maybe a little fatigue and dizziness but it was always "explainable". I wouldn't even have gone to the doctor then if it weren't for numbness/tingling in my hands. I work on a computer all day so it was very annoying and I broke down and went. And after a few MRIs and other tests this is where I am.
Avatar n tn Okay, I've had MS for 13 years. I was just taken off Tysabri in July, I was on that for almost 5 years. I now have to go on Gylena in January, but before I start the new drug...I have to do 6 months of iv steroids. 3 days every month with NO taper! I have just finished my second round...and I'm ready to through in the towel. The side affects of the steroids are at this point almost not worth doing. They are trying to prevent a relapse since I am not on any MS therapy.