tysabri jc virus

I wonder if you can still get treatment with Tysabri if you test positive for the JC Virus. My sister has been on Tysabri for three-four years now and is positive for the JC Virus. She's got nothing but great things to say about the drug . . .

I got the official JC virus results, and I am JC positive. We are still staying with the Tysabri at this point, since we feel it is helping me.

This was an interesting report - it was also reported via MedLine in perhaps an easier format to understand ---- http://www.nlm.nih.gov/medlineplus/news/fullstory_125250.

Is your CSF JC positive as well? That is being reported as a more sensitive indicator of the JC virus. The first 24 months are the safest when JC negative. There is an alogirthm for the chances of contracting PML while on tysabri. I believe it is on the tysabri website among other places. I will see if I can find it for you and report back.

Kate, your friend hit the lottery with being JC Virus negative. There has not yet been a single case of PML reported of anyone who is JC Virus negative. This is an important item to discuss with the treating neurologist. I'm glad Rita came out and offered to talk with you about her experiences. Please consider taking her up on it - she is one of our resident experts on Tysabri, and is always willing to chat privately.

i have read up on tysabri and i dont like when i have read,they drew blood today to check for the jc virus.

s great that you are JC negative! When was the last time you were tested for the virus? The FDA has just recommended that people on Tysabri who are JC negative should be re- tested every 6 months, since it is a common virus that you can be exposed to at any time. So I would definitely keep up on that if you stay on Tysabri. Were you on any kind of treatment prior to Tysabri?

Or the JC Virus? My neuro said he thinks that sex can increase your risk of becoming positive, however in studies ive read it looks like theyve found a link between the virus and contaminated food/water.

In the time I have been taking Tysabri, they have obtained much more data, as more and more people began taking Tysabri and staying on it longer. The JC virus test has been very helpful, allowing people who are negative to go on Tysabri with much less worry of PML, as well as giving people who test positive a better idea of the risks and allowing them to make more informed choices and decisions. At this time, they have identified 3 main risk factors for PML while on Tysabri: 1.

HOWEVER if you continue to test negative for the JC Virus there is no reason you should have to stop tysabri if it is working for you. In fact, stopping Tysabri is shown to cause serious relapses and is not something fun to go through. I would talke to a different doctor about tysabri and get off the holiday idea. Of course if you test positive for the JC virus, that is a different story entirely. good luck in working this through with your medical provider.

I'm glad you stuck that up for discussion - I glanced at it briefly yesterday and thought it was significant. It made me think of you, Kyle, with the repeat LP to check for the virus. I'm due for my next JC virus assay in July- I hope it continues to be negative, but I will definitely ask a few more questions than usual.

My Neurologist is not a big fan however. She will suggest almost anything before discussing Tysabri, but now with the JC virus test, she seems to be warming up to the drug. I am going to put it off for a while and think about it. Luckily I haven't had any immuno-suppressant treatments so getting a negative JC test would certainly make me a good candidate for Tysabri. I just want to give IVIG a bit more time.

Friday I called my neuro to find out if they want me to do a washout period on Tysabri, as they are considering me for the new drug out in March. I've ben on Tysabri almost a year and JC+ from the start The nurse told me my test showed 1.03. which means nothing to me. Anyone know anything about this test?

The equivocation comes from the occasional false negative of the JC blood test, so that the very rare person with PML and a negative result on the JC virus mostly likely actually has the virus which was not detected. There was some thinking that a Tysabri vacation could help prevent PML. I have not seen this evidence. Now - what I am about to talk about is not published and no one should act on it, but it is very interesting.

Does anybody have any experience with Tysabri? I just tested positive for the JC virus and my doc still wants to put me on it for 6 months. He says that the risk of getting the brain infection is very low since I will only be on it for a short period of time. My other option is to go on Gilenya, I am not sure what to do.

I just got the results of my JC virus test, and I am JC positive. Even so, both my neuro and I feel I would be doing alot worse if I wasn't on Tysabri, so at this point I am staying on it. It has not always been an easy ride, but we still feel it is the best thing for me at this point. I have to go get ready to head out, but will be happy to answer any questions you may have. Feel free to PM me if you'd like.

Most DMDs do not suppress the immune system Tysabri can make you more suceptible to the JC virus. Gileyna to herpes. The CRABs do not make you more suseptible to illness. They all have different mechanisms to keep your immune system from attacking your T and B cells. Each works differently. Some block the action, some act as decoys, etc. It is confusing. Each person with MS is different. I for one am pretty healthy from infections.

I was on beta seron for months.. Now starting tysabri.. No I don't carry jc virus. Anyone have input on this? My lesions are in brain and cervical spine is a mess with lesions. Arms n hands are awful. Have had the hugs as well. And the almighty "zapper", the elect current that runs through torso and hits you in the pelvic area. This disease is quite difficult to keep up with. Here then there then another area...

I'm just curious - what kind of study are you involved in? I'm on Tysabri too... just had blood drawn for the JC virus antibody study. Is that the one you are talking about?

She told me I was negative for the JC virus and would like to know my thoughts about this. Would I be willing to try Tysabri? She knows I was overloaded with info at the last visit and wants to go over all this. She said she has done lots of "thinking" about what med would be most effective for me. I appreciate her doing her job so well. I have total trust in her, but am really nervous about this med.

There are several of us here on Tysabri - I made the switch after about three years on copaxone. It takes a day a month to stop and have the infusion, and then I go on ny way for another 4 weeks. So far, even though some of my symptoms continue to progress. my MRIs are stable with nothing new that would excite me or my neuro. I am also JC negative, hitting my two year mark, and plan to stay on it until I have to stop.

I've been on Tysabri for 28 months and continue to test negative for the JC Virus, so it is a no-brainer for me. They screen for JC and liver function every six months but would do it more if I reguest. Kat mentions what I like best - besides that it is working for me - is this is just one day a month that I set aside to do my infusion and then I don't think about it again for another 27 days. I don't have that constant reminder with daily injections that I am sickl.

I just saw a MS neuro at OSU hospital. He asked me whether I was interested in being in the Tysabri study. I am only 37 and have only had one relapse. I know I will be deciding on a treatment and not sure what direction to go. This neuro is big in research and he spent a lot of time talking with me about MS. He mentioned a JC Virus and took my blood to look for it. If I don't, I would be a good candidate for Tysabri. It has 67% reduction in relapses but also risks getting PML.

Recently I tested positive for the JC virus. It is terrifying news. I have decided to say on Tysabri, and get tests done much more frequently, for now, because I hate the idea of being trapped in a wheelchair as much as the idea of dying from pml, but I don't have to live past dying. :P I know it's not a good choice, but there isn't anything better right now (or even anything as good).

Tysabri jc virus

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