My lesions were increasing and I still had the fatigue that went along with MS. Ive been on
Tysabri for almost 4 years with no flare ups.
For having MS, I feel great. I used to get monthly blood work to check for PML and would take 2 to 3 month "holidays", just so my body wouldn't be over exposed to the Tysabri. (It lasts in your system for up to 3 months). I recommend Tysabri to anyone that has MS. It beats daily self injections, and its only once a month.