tysabri europe

At the end of July 2008, it was revealed that there were 2 new cases of PML in Europe - in people who were on Tysabri as their only treatment. In Europe, the program to oversee Tysabri is not as stringent as the TOUCH program is here in the US, and that may play into the scenario. There are a number of details that have yet to come out. One of the patients in Europe is recovering pretty well at this point, and one of them is doing very poorly.

Tecfidera will not be made available in Europe until later this year, according to these headlines. Biogen is seeking to get patent protection for their drug before its commercial release. The details are in this story from Reuters. http://www.reuters.

I have never heard of a brain infection related to Gilenya … perhaps the doctor was referring to Tysabri, although a doctor should know the difference. Tysabri also may be worth a try. Yes, it has shortcomings, but like Gilenya, many people tolerate it well and have good results. I don’t know anything about gabapentin, other than that it is not a disease-modifying drug interchangable with Gilenya, Tysabri, Copaxone, Avonex, Rebif, and Betaseron.

Hey Guys, Just wanted to give you all a heads up, in the interest of us all being informed patients... :) I saw this article this morning, and here's the crux of it: "New Case of PML Confirmed in U.S. A new case of PML, or progressive multifocal leukoencephalopathy, has been confirmed in the U.S., in a patient receiving Tysabri for the treatment of MS. After 14 treatments, the patient reported a change in health status, and the patient’s physician began testing for PML.

As of now there have been two additional cases of PML an often fatal viral brain infection in Europe in two people who had been taking Tysabri for 14 months and for 17 months. So, currently the infection rate is 2 people per 6000 taking it. This is less than the "label warning" of 1 per 1000, but it really does dash the hope that the prior cases occurred because of the simultaneous use of other immune-modulating drugs. Phooey.

I would like to hear about Lemtrada and how it ends up working for you. I bet you missed Diesel. It is going to be real weird when I go to Europe for three weeks with out my dogs. Luckily we have a live in pet sitter.

Hello, all! I was originally diagnosed with primary progressive multiple sclerosis in May 2007, when I was 26 years old. That diagnosis was changed to progressive relapsing multiple sclerosis in October 2007, when I had an exacerbation. My neurologist has never been completely comfortable with my diagnosis, because I don't display "typical" MS in many ways. My first MRI showed more lesions along my cervical spine than in my brain, but my spinal tap displayed (?

Studies have just been released noting that psoriasis patients in Europe have come down with PML after using the drug Fumaderm. A key ingredient is the dimethyl fumarate also used in Tecifidera. The media are jumping all over this, and Biogen stock was affected adversely. However, other ingredients are not the same. The FDA was aware of the Fumaderm issues when it approved Tecfidera.

Not to mention, that I will soon run out of good sites. I am a bit afraid of the Tysabri. Though she says there have 6 or so episodes of PML, some were Europe where they don't have the Touch program and pt are not followed as closely. She says 83% of users have no flairs in a 2 year study. She will see me monthly or sooner of course if necessary.

Yay! I for one AM switching treatments. Good-bye needles. Ordinarily I'd be in the 'stand back and see how it goes for others' group. This is different, for me, because the same drug has been used for years now in Europe to treat psoriasis. so there's a lot of track record out there. I know there can be side effects, not serious ones, and probably fleeting if they happen at all, and I'll have to deal with that if and when. For now, I'm just glad.

He decided it was time to try Tysabri. So last June he sent me to UCSF to check if I could go in the program and I got in right away. I saw my regular neuro again in July and his attitude was like...well they have control of your meds now so what do you want me to do for you?? HHHMMMM you scheduled a follow up appt, so I came. So he did reschedule me for 6 months out anyway. I went to UCSF to get a brain MRI and check up on Jan 5th. Brain MRI looks like no changes...

I have had MD for 18 years. Been on Avonex, Betaseron, Tysabri, and now Tecfidera. Unfortunately, I'm also on lots of other medications, mostly due to terrible central pain. My neurologist made me stop the Tysabri after 24 infusions because of safety concerns. I felt my overall best while on Tysabri and have asked him if and when I might be able to go back on the monthly infusions. He does not have an answer for me at this point.

Are any of you on Tysabri? My doctor has suggested that I consider starting Tysabri treatment. His neurology practice runs a TOUCH infusion center. I've been on Copaxone for four years and have just had my first flareup. My recent MRI shows progression of MS with T2 hyperintense white matter lesions in the pons of the brainstem and the frontal lobe. Several of the older lesions have increased in size. Five years ago I was on Avonex. I had multiple flare-ups the whole year on this med.

I would like some information/details from anyone who has had (or seen) the rash you can get from Tysabril and/or PML?? I have been on Tysabri 10 years so far without any major issues. I was outside after my treatment for 10 minutes or so. After taking my shirt off, my husband gasped and asked what was wrong with my back.

I've been tested twice in the last year, and they were both negative. Since you can acquire JCV at any time, I opt to have my status tested once a year since I'm on Tysabri. There is also a Tysabri antibody titre available, now. I plan on doing that once a year, too, although development of Tysabri antibodies is relatively rare.

My new neuro suggested Tysabri based on increased lesions on Interferon (Rebif). Any persons out there on Tysabri that could share their experience?

He feels that Tysabri is the way to go. I know that there are others here on it or used to be. I would love some insight on what to expect, how long it takes, etc... Thanks!

I will start tecfidera in 3 months I hope I dont have the rebound effect I have heard about after stopping tysabri. Tysabri has really changed the way I feel was using a walker now nothing and I do Zumba too. I hope I stay like this but having doubts. anyone using tecfidera? How was your experience.?

So now he wants to take me off of the Copaxone, I have been on for a month and a half, and put me on Tysabri. I started the application process and now waiting for them to call me and get the ball rolling on that. Now he mentioned that this is the top of the line MS medication so that does give me some relief. P.S. I did test negetive for the JC Virus. Any thoughts, experiences etc on this Tysabri??!!

The research side of my MS Practice has identified a CSF biomarker for disease activity. The research is featured on the cover of this month's Multiple Sclerosis Journal. http://tischms.org/news/tisch-ms-breakthrough-biomarker-research-featured-cover-article-october-2013-issue-multiple I'm a beneficiary of this discovery. I had been on Tysabri for 20 months. At 18 Months I converted to JCV +, and we discussed switching from Tysabri to Tecfidera.

side effects for each other medicine and now this with tysabri. Has anyone else been on tysabri and developed c. Diff from it? If so, what did they do to help it? Stop tysabri? Any information would be greatly appreciated.

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