Tysabri chemotherapy

Common Questions and Answers about Tysabri chemotherapy

tysabri

Avatar n tn I had been on Tysabri for 22 month's and just recently stopped. I was wondering if any new info. is out there on the drug Rituxan for MS? I have SPMS with RRMS. I was in a study 3 yrs. ago at UCSF and did really well on Rituxan. However, Rituxan is not an approved drug for MS and at that time my insurance would not cover it so I had to discontinue taking it. Or should I just take a break for awhile and not take any ms med"s?
572651 tn?1530999357 The Biogen Idec lunch talk I went to today was very interesting and quite a different approach than the usual tons of slides about Tysabri. It focused on what those numbers in clinical trials really mean. Of course it was directed at explaining why the Avonex number and Tysabri numbers are what they appear to be, but it really got me thinking.
1115136 tn?1258778476 After my first exacerbation in October 2007- when they changed my diagnosis to progressive relapsing MS- my doctor put me on Novantrone, which is a type of chemotherapy. I had one dose every three months, and after I had a total of three doses, I weighed 98 pounds (I'm 5'6"), so we had to stop. I've been having steroid infusions since, and now I have one steroid infusion, once a month.
Avatar f tn Things that suppress the immune system like Tysabri, chemotherapy and now the oral MS meds can have many serious and fatal infections and even things like lymphoma (an often fatal cancer of the lymph nodes) are things to be VERY cautious about. The simple, uncomplicated oral med for MS is not even on the horizon. Don't get too optimistic. Remember the 4 main DMDs, Avonex, Betaseron, Copaxone, and Rebif do NOT suppress the immune system in any major way.
Avatar f tn m aware of who had a port implanted to receive Tysabri infusions. It was done when the monthly hunt-stick-miss-hunt again-stick again method of inserting a temporary line became too painful and burdensome to bear. I've never had a med-port but my sister had one placed for chemotherapy treatments - twice. She said the surgery itself was more uncomfortable than her (partial) mastectomy - not terrible, mostly just took her by surprise.
Avatar m tn The injections only work 33% if started at the beginning stages of Relapsing Remitting MS. There is Tysabri an infusion and their are drug trials for oral medications. Sometimes they can even use chemo but it is rough stuff. Unfortunately to date these are the only proven treatments. Some people go to other countries to get stem cells. The problem is stem cells can't repair damage they can only in some cases slow future damage but usually only for awhile.
Avatar m tn She said I could still do Tysabri for a couple of years. I declined. Then she wanted me to do Tecfidera. There have been at least 5 cases of PML in patients treated for psoriasis with Tecfidera (different brand name, same generic drug though). Now there has been a case of PML in the US in an MS patient being treated with Tecfidera. My doctor talks to me like I'm an idiot because I'm just not real excited about doing one of the drugs even though I'm JCV +.
Avatar f tn They found out the reason people contracted PML was because they were taking Avonex/and the other MS medications with Tysabri. I think the Tysabri has given me a second chance at helping slow my disease progress, but with out it I would be on no MS medications to slow the disease. I did alot of research before I decided to start the medication and the one resource that helped me make my decision was reading the Tysabri diaries on line. www.msrc.co.uk/index.cfm?
Avatar f tn I have had MD for 18 years. Been on Avonex, Betaseron, Tysabri, and now Tecfidera. Unfortunately, I'm also on lots of other medications, mostly due to terrible central pain. My neurologist made me stop the Tysabri after 24 infusions because of safety concerns. I felt my overall best while on Tysabri and have asked him if and when I might be able to go back on the monthly infusions. He does not have an answer for me at this point.
Avatar f tn Are any of you on Tysabri? My doctor has suggested that I consider starting Tysabri treatment. His neurology practice runs a TOUCH infusion center. I've been on Copaxone for four years and have just had my first flareup. My recent MRI shows progression of MS with T2 hyperintense white matter lesions in the pons of the brainstem and the frontal lobe. Several of the older lesions have increased in size. Five years ago I was on Avonex. I had multiple flare-ups the whole year on this med.
Avatar m tn I would like some information/details from anyone who has had (or seen) the rash you can get from Tysabril and/or PML?? I have been on Tysabri 10 years so far without any major issues. I was outside after my treatment for 10 minutes or so. After taking my shirt off, my husband gasped and asked what was wrong with my back.
572651 tn?1530999357 I've been tested twice in the last year, and they were both negative. Since you can acquire JCV at any time, I opt to have my status tested once a year since I'm on Tysabri. There is also a Tysabri antibody titre available, now. I plan on doing that once a year, too, although development of Tysabri antibodies is relatively rare.
712568 tn?1268104907 Actually, a number of chemotherapy drugs have been tried for MS. Novantrone, as mentioned, is one. I believe it is used for the progressive forms, but has cardiac issues associated with it. Methotrexate, Azathioprine (Imuran), and Cyclophosphamide (Cytoxan) are others that have been used to try to suppress MS activity. Then there are the monoclonal antibodies. Tysabri (natalizumab) is one of these. Rituxan and Campath, which is showing promising results for RRMS, are also being used.
1827617 tn?1317703371 My new neuro suggested Tysabri based on increased lesions on Interferon (Rebif). Any persons out there on Tysabri that could share their experience?
1760800 tn?1406753451 He feels that Tysabri is the way to go. I know that there are others here on it or used to be. I would love some insight on what to expect, how long it takes, etc... Thanks!
1088527 tn?1425313375 I will start tecfidera in 3 months I hope I dont have the rebound effect I have heard about after stopping tysabri. Tysabri has really changed the way I feel was using a walker now nothing and I do Zumba too. I hope I stay like this but having doubts. anyone using tecfidera? How was your experience.?
Avatar f tn So now he wants to take me off of the Copaxone, I have been on for a month and a half, and put me on Tysabri. I started the application process and now waiting for them to call me and get the ball rolling on that. Now he mentioned that this is the top of the line MS medication so that does give me some relief. P.S. I did test negetive for the JC Virus. Any thoughts, experiences etc on this Tysabri??!!
1831849 tn?1383228392 The research side of my MS Practice has identified a CSF biomarker for disease activity. The research is featured on the cover of this month's Multiple Sclerosis Journal. http://tischms.org/news/tisch-ms-breakthrough-biomarker-research-featured-cover-article-october-2013-issue-multiple I'm a beneficiary of this discovery. I had been on Tysabri for 20 months. At 18 Months I converted to JCV +, and we discussed switching from Tysabri to Tecfidera.
Avatar f tn side effects for each other medicine and now this with tysabri. Has anyone else been on tysabri and developed c. Diff from it? If so, what did they do to help it? Stop tysabri? Any information would be greatly appreciated.
4848471 tn?1372238752 There is an alogirthm for the chances of contracting PML while on tysabri. I believe it is on the tysabri website among other places. I will see if I can find it for you and report back.
1831849 tn?1383228392 I had my 5th Tysabri improvement last Sunday. Since then I have noticed a major improvement in the way my legs feel and work. I mean a major improvement. My legs have not felt this good in a very long time. I have also been exercising regularly for the last month and have lost a bunch of weight. I'm trying to determine to what I can attribute the improvement. Is it the Ty infusion? The exercise? the weight loss? I'm kinda hoping it's the Tysabri.
Avatar f tn Friday I called my neuro to find out if they want me to do a washout period on Tysabri, as they are considering me for the new drug out in March. I've ben on Tysabri almost a year and JC+ from the start The nurse told me my test showed 1.03. which means nothing to me. Anyone know anything about this test?
147426 tn?1317265632 There have been a number of serious brain infections on Tysabri and a few daths from it. Novantrone IS a chemotherapy agent, it is immune suppressing and it carries a definite risk of toxicity to the heart. I hope this helps answer your questions and those of the people you talk to.