It also mildly inhibits the reuptake of serotonin, similar to SSRI antidepressants.
Both <span style = 'background-color: #dae8f4'>hydrocodone</span>
and oxycodone are also synthetic opioids
that act solely on the mu-opioid receptor.
All three medications, tramadol
, and oxycodone will cause opioid dependence with extended use, which will cause withdrawal symptoms on discontinuing the medication, and withdrawal from tramadol
is no easier than withdrawal from hydrocodone