I've been on Topamax for over a year now and it did that to me at first too, the numbness or tingling, mostly in my toes, I started out at 50mg. and now have been on 75mg, for 6 mos. I will say for me, those side effects have gone away and personally the good out ways the bad, you see, I had a mild stroke from the migraine I had, I have hemiplegic migraines and to me it is worth a little discomfort rather than go through that again!