Down Syndrome, Beckwith-Widemann Syndrome, Mucopolysaccharidoses, and many more
- Hypothyroidism – due to accumulation of matrix glycosaminoglycans
- Infiltrative disease – AL Amyloidosis, Sarcoidosis
- Neoplasms of the tongue
– Carcinoma, Plasmacytoma, Hemangioma
- Trauma – Surgery, biting, intubation injury, radiation therapy
- Infection – Ludwig Angina, Candidiasis, more
- Vitamin Deficiencies – e.g.