Thyroid peroxidase antibodies
Common Questions and Answers about Thyroid peroxidase antibodies
armour-thyroid
I just received a phone call from the docs saying they reviewed my bloods and found peroxidase antibodies (280). My tsh when it was last tested 2 months ago was 2.51 with a t3 of 14.4. What does this mean and could it cause my symptoms? I'm getting so frustrated and it is so difficult getting help especially with two little ones to look after, I'm so desperate to find an answer.
TPO ab is a test that evaluates the level thyroid antibodies of that type. Thyroid antibodies do not directly cause hypo symptoms like you mention. The antibodies do attack the thyroid glands and continue over a period of time until the thyroid glands are destroyed. During this period of destruction, your normal thyroid hormone production is gradually going down, requiring gradual increases in thyroid meds to offset the loss of normal thyroid production.
Last week my ob/gyn ordered the basic TSH test because my cycle is changing and due to a 30 lb weight gain in just 2 1/2 months. I have had thyroid testing completed in the past and have been told I'm fine. I read an article about the TSH norm being changed so I wondered if my previous levels fell into the "abnormal" range, which they didn't. In 2004 my TSH was 1.55 and in 2007 it was 1.32. I understand that this is apparently normal.
My thyroid peroxidase antibodies level is 360 and my thyroglobulin antibodies level is 81 on my most recent CBC done by Gynecologist. She suggest going to general physician with result, but should I find a specialist, if yes, what type? What do these results indicate, she mentioned Hashimoto's . I also have anemia issues!!
About two weeks after that, I had some regular blood work done by my doctor in an attempt to get information on a miscarriage that I suffered at the end of last year. The blood work revealed that I have an elevated level of thyroid peroxidase antibodies. Could the thyroid antibodies have given me a false negative on my HIV test? All other blood work was normal, and my HIV exposure was over a year ago. Thank you for your help!
Some people without thyroid disease may have TPO (thyroid peroxidase) antibodies. However, the presence of thyroid peroxidase antibodies may increase the risk of future thyroid disorders. If you have normal thyroid function with TPO antibodies, your doctor may recommend periodic checkups to watch for future thyroid problems.
Do you know if they drew a TSH blood panel as well or was this normal or abnormal as well?
It means you have antibodies against your own thyroid, you have probably Hashimoto thyroiditis. Now you need to check your TSH, free T3 and free T4 and make an ultrasound of your thyroid. I have high Thyroid peroxidase antibodies (TPO) and I'm not sick (.....yet). Read this: http://www.mayoclinic.
my test results showed antithyroid peroxidase 202, could just tell me what this signifies,as im unaware of it at all.
The antibodies are attacking your thyroid causing it to malfunction and thats why you are on Eltroxin (thyroid replacement).
Whereabouts are you as Eltroxin is usually prescribed in New Zealand?
I just received my lab results , the thyroglobulin antibodies was 2235 , and the thyroid peroxidase was 159 . The thyroid panel , T-3 uptake 31 , T-4 8.2 and Free T4 Index was 2.7 , which are in range. So what does having high thyroglobulin, and thyroid peroxidase mean . My doctor refer me to an endocrinologist, but it will be another week before I see them. Can someone please explain what the results mean.
There are many types of thyroid antibodies, but the three most prevalently tested are Antimicrosomal (thyroid peroxidase or TPO) Antibodies, AntiThyroglobulin Antibodies, and Thyroid Stimulating Immunoglobulins. The first two make you Hypo, and the last makes you Hyper. The presence of TPO antibodies is also called "Hashimoto's Thyroiditis."
Hope this helps.
Hi Atma108,
First, I would like to say that there is no reason to believe that this is thyroid cancer. Hypothyroidism, anti-thyroid antibodies, and thyroid cancer can all be completely independent of eachother, although having antibodies against your thyroid can result in hypothyroidism (or in some cases hyperthyroidism).
The most common cause of hypothyroidism in countries who add iodine to salt is an autoimmune disease called Hashimoto's.
The Synthroid is to offset the loss of natural thyroid hormone as your thyroid glands are being destroyed by the antibodies. Some Hashi's patients have reported that selenium seems to reduce the level of antibodies, but that is only anecdotal info. Also, if you consider selenium you need to do so cautiously, since it can be toxic when excessive.
Frequently hypo patients find that TSH will be suppressed when taking thyroid meds.
Thyroid peroxidase antibodies (TPOAb) and thyroglobulin antibodies (TgAb) are attacking thyroglobulin and thyroid peroxidise which are found in the thyroid gland. These antibodies usually disappear once all the thyroid tissue is removed.
Thyroid-stimulating immunoglobulin is another antibody that can stimulates the thyroid gland to produce more thyroid hormone, bind to the eyes (thyroid eye disease) and under the skin - typically on the shins (pretibal myxedema).
The TPO gene provides instructions for making an enzyme called thyroid peroxidase. This enzyme plays a central role in the function of the thyroid gland, a butterfly-shaped tissue in the lower neck. Thyroid peroxidase assists the chemical reaction that adds iodine to a protein called thyroglobulin, a critical step in generating thyroid hormones. Thyroid hormones play an important role in regulating growth, brain development, and the rate of chemical reactions in the body (metabolism).
It's a strong positive. Typical reference range for antibodies is 0-34. However, don't freak out about the very high number. That's not unusual at all. My TPOab (thyroid peroxidase antibodies) was over 900, and my TGab (thyroglobulin antibodies) was 3,000+ on diagnosis of Hashi's. Antibody counts are typically very high.
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