In contrast to hyperthyroidism, liver biochemistry abnormalities are less prominent in patients with hypothyroidism. However, modest elevations in serum AST
and ALT have been reported in 84%
and 60%, respectively, of patients with hypothyroidism[88]. Some patients may show low serum ALP[87], but their most characteristic symptom is ascites, which is caused by unknown mechanisms[87]. In addition, cholestatic jaundice has been described in case reports of patients with severe hypothyroidism[17].