The friend I grew up with, in his late 40's, was constantly complaining of his belly hurting, he was throwing up
, the docs had already told him several years earlier that he needed to have his GB out, he wouldn't go, he hated doctors, hated the hospital, etc. One day he was in severe pain (gut pain) had high fever, he was hospitalized and taken to surgery. He developed septicemia due to peritonitis from GB disease. He never made it out of the hospital.