Tarceva for brain cancer
Common Questions and Answers about Tarceva for brain cancer
tarceva
m doing research as quickly as I can to help she and her husband make an informed decision about what to do...if anything. The local drs are recommending 4 weeks of full brain radiation followed by tarceva. Prior to the finding the mets, they were planning 6 weeks of radiation to the right lung in combination with etoposide and cisplatin.
I'd appreciate any feedback. My thanks in advance to all responses....
Asians, women, non-smokers, and those with adenocarcinoma histology. This drug still has been found to benefit males, smokers, and those with squamous cell histology, but to a lesser extent.
Thanks for your response. To clarify: his treatment was adjunctive. At the time they saw no sign of cancer outside the lung. Now, however, after 4 rounds of chemotherapy the disease seems to have spread during treatment with taxotere and cisplatin: it's now in the liver, bones and adrenal glands. His original tumor was EGFR positive that is why Tarceva came up as a viable second step.
In general, this would represent the recommended treatment options for lung cancer. There are no clear guides as what drug is best after 3 lines of therapy, hence the reluctance to recommend any treatment.
I am also guessing that the adrenal involvement cannot be removed with surgery, hence, this is not given as an option. You are right, that there are some people who even have brain involvement and undergo surgery, but these cases are really the exceptions more than the rule.
Edema (fluid accumulation in any body part, resulting in swelling) has been reported as an adverse event in 37% of pancreatic cancer patients taking Tarceva, although this side effect has not been reported in lung cancer cases.
However, the type of edema associated with Tarceva use is either generalized or involves a swelling of both legs. Swelling in only one leg may not be due to this drug. Unilateral leg swelling may be due to a local infection (cellulitis) in that area.
My father who is now 83 yres old is diagnosed with non small cell cancer with a large 3 inch mass in his upper right side. They state it is somewhere between a stage 2 and 3 due to the size. He is schedules to start radiation treatment in a week. However, they did state he is fit enough to have sugery but there is not guarantee he would not have complications from this. We are struggling to determine what is the better path to take. Will the surgery give him a better chance vs the radiation.
He started Tarceva this January but it seems it did not work as the cancer spread to brain…. 9 mets were identified in the initial MRI 2 weeks ago but the subsequent MRI right before yesterday’s gamma knife procedure (which removed 7 mets) evidenced numerous other tiny/small tumors spread all over the brain….He has been in relatively good condition (eating well, no weight loss) until these new mets emerged (which affected his walking and reading ability)….
It has already spread to the spine, both lungs and the lymph system. Doctors triede Tarceva for 3 weeks but her body had a very bad reaction. For the spine they did radiotherapy. But since she was diagnose 3 months ago she has lost aalmost her voice. she is using oxygen for the major part of the day but doctors don't wan't to talk about time. no more medes will be given and she was reffer to hospice....
Hi There...
I have had a upper right lobectomy on Sept 14 2001.Stage 1A BAC lung cancer...no chemo or no radiation..clear margins and no lymph node involvement.. ..it's been a little over five years now. cancer free. PRAISE GOD...and thou I realize that 5 yrs is maybe the magic number for most lung cancer survivor's...is it also meant for BAC Lung Cancer...I have heard not so....
Thank you for any information you can give me....
Hi, My 69 year old Dad has stage 4 Lung nsc cancer that he has been battling for over 2 years with good results from first Tarceva, then Chemo and prior to that radiation to mets to his brain. He is an otherwise healthy, robust, nonsmoking person. Last month he started experiencing problems walking, nausea and headaches. He was referred to a Neurologist who recommended a Shunt to help regulate the fluid in his brain. It has been a nightmare ever since.
Hi. Which particular "chemosensitivity test" are you referring to? There is no single laboratory procedure which can test for the sensitivity to chemotherapy of all types of tumors. In breast cancer, there's the Estrogen Receptor (ER) and Progesterone Receptor (PR) assays to determine sensitivity to hormonal treatment. There's also the HER-2 (human epidermal growth factor receptor 2) assay for determining sensitivity to Trastuzumab.
Hi,
Your concerns are valid. Lung cancer is afterall, the biggest cause of cancer mortality. For this post, I can only work with the stage information, your doctor likely has better estimates.
Much of the answer here depends on how much the disease is affecting her daily living. If she stays in bed most of her waking hours, then treatment may only make an impact on symptom improvement. If she is able to maintain a fairly active lifestyle – then treatment may help extend survival .
She is not a candidate for treatment and is refusing even palliative tx such as Tarceva. PET Scan showed no evidence of cancer in brain, liver or bone. Because she is experiencing no symptoms she is hesistant to participate in a home hospice program. What symptoms are generally experienced and if possible a general timeline for disease progression.
-\ Anyway, its nice to know i have people out there who really care. I wish there was one of these sites for cancer patients. There probably is but im rarely on the computer. If any of you all are interested, my sister put up a website for me called Gina's Angels. It talks about how im doing and shows pictures and stuff. Id love for you to check it out and maybe "like" the page on fb. My love to all of you!
Thanks for your revert. She had original case of Overy cancer for which she was operated and underwent 3 pre surgery and 15 post surgery cycles of Chemo. Post which she was confirmed as cured for that, however she had developed a lesion in the right frontal lobe which was effecting her left side of the body. She underwent a gama knife surgery, post which she was given steroids and Valporin. She was recovering well for around three months .
Recommended
