t tolerate Synthroid at all. I was on a
Cytomel and Levothyroxine combo previous to
Synthroid. I had a few issues sleeping, being on Cytomel, and felt I should try and convert my own T4 to T3. So I started Synthroid exclusively. I took it and initially felt a little better, at least the sleeping and such. But after about 3 weeks, I started with severe bloating and arthritis in my hands and hip joints. I'd never before had hip joint pain...EVER before Synthroid.