Tacrolimus vs cyclosporine
Common Questions and Answers about Tacrolimus vs cyclosporine
prograf
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine. [both drugs are calcineurin inhibitors]
* omeprazole (Losec, Prilosec)
* oxycodone (Oxycodone is metabolized by the cytochrome P450 system, specifically CYP3A4, of which the bergamottin flavonoid is a strong inhibitor)
* hydrocodone (The hepatic cytochrome P450 enzyme CYP2D6 converts it into hydromorphone, a more potent opioid.
Newer two topical eczema drugs like pimecrolimus (Elidel Cream) and tacrolimus (Protopic Ointment) are reserved only for cases where corticosteroids have not been effective.
Sometimes oral corticosteroids and immunosuppressants like cyclosporine and phototherapy are used for resistant cases. Your doctor may prescribe some sedative-antihistaminics to reduce itching. You may discuss about these treatment options with your doctor.
Hi
When topical corticosteroids do not provide relief, sometimes more the doctor may consider prescribing some more potent corticosteroids for some period, in adults with may be needed for adults with eczema on the scalp, limbs, and trunk or those with chronic/ lichenified eczema. Newer two topical eczema drugs like pimecrolimus (Elidel Cream) and tacrolimus (Protopic Ointment) are reserved only for cases where corticosteroids have not been effective.
Thank you for the update. I am so sorry to hear this sad news.
Thats why we am trying to find out all we can as we are set for early August.
We put Tacrolimus & cyclosporine (6:00AM, 2:00pm & 7:00PM) three times a day and Teargel/Severe every hour starting at 7:00AM untill 10:00PM. So we know about not bring able to go places and travel.
I am starting to put out questions in other forums. If I find anything I will inform you.
I hope Casper can make a recovery!!
So I guess patients with allergic reactions are like patients who have graft vs. host disease ? It makes me wonder if anti-rejection drugs like cyclosporine would help these people suffering from severe allergies ?
I agree that there is some immune dysfunction in allergies. I guess what bothers me is that an estimated 60% of the population now has allergies and there are more and more cases of food allergies diagnosed in children now.
Newer two topical eczema drugs like pimecrolimus (Elidel Cream) and tacrolimus (Protopic Ointment) are reserved only for cases where corticosteroids have not been effective.
In resistant cases, oral corticosteroids and immunosuppressants like cyclosporine and phototherapy are used. Since you are having intense itching, your doctor may prescribe some sedative-antihistaminics to reduce itching. You may discuss about these treatment options with your doctor.
t read anything definitive about the impact of tacrolimus on treatment outcome in the transplant population. There are articles which suggest that Cyclosporine may have benefits over Prograf insofar as recurrence of HCV post transplant is concerned but, I haven't seen anything related to HCV treatment response. I think I would play it safe and keep it simple and just do the treatment with Prograf. Good luck.
About 6 months ago, I was finally diagnosed and started taking cyclosporine 100 mg 2x day. After a week, I could eat like a normal person—just about anything I wanted. It was great, it even allowed me to travel to Europe. The cyclosporine I was taking was a powder in a capsule, apparently this has been taken off the market and instead I took the same medication, but it was in the form of a capsule with alcohol. Unfortunately, after a short time, I was right back to before treatment.
Yes I took Cyclosporine for my aquagenic urticaria, it helped so much but not enough to have a normal life :S but maybe for you its going to be different...
One of the principal concerns with these drugs is their possible interaction with immunosuppressive drugs such as cyclosporine, tacrolimus, and sirolimus. Given that cyclosporine drug levels are increased only 4-fold when this drug is coadministered with telaprevir (Incivek, Vertex; compared to a 70-fold increase for tacrolimus), cyclosporine seems to be an attractive choice for HCV-infected transplant recipients who are planning to use a protease inhibitor.
I don't believe that OH is treating with a PI.
The PIs can increase plasma levels of tacrolimus and cyclosporine very significantly - to toxic levels. There's a lot of research regarding dosing that needs to be done before these drugs will be used in the transplant population.
I am still on 100 mg 2x daily cyclosporine. My cyclosporine through levels have been lower, the last time they were at 79. I Have been on 300 mg ursodiol 3x daily for biliary stricture since tx. I lowered the dose to 300mg once daily but just recently raised it back to 300x 3 daily because right side discomfort an increase in bilirubin. My headaches and fluid in ears have gotten better, still have the vision issues but heart palpitations have also lessened.
Can tacrolimus eye drops and Cyclosporine ointment cause cancer in dogs? My precious dog, baby and best friend was diagnosed just last week with Transitional Cell Carcinoma in his bladder. It is a rapid growing cancer. I am completely heartbroken and am wondering if there was something I could've done to prevent this. He has been on these two eye medications for about a year. His name is Duke and he is a beautiful tri-colored collie and is a little over 10 years old.
i wouldnt lower the tacrolimus dose further
Close to five years post liver transplant. No rejections, cyclosporine mono -therapy .Also take 300 mg ursodiol 3x daily for bile duct stricture. Vascular hyper-tensions are becoming a real concern. ie heart, palpitations . fluid in ears , vision problems that aren't related to my actual eyes, the opthamologist confirmed, Migraines that have actually gotten better lately. kidney function is still adequate. My liver is doing very good especially with hep-c..
and the vet will probably prescribe cyclosporine drops to help the eye produce more tears. Before you use the cyclosporine drops, be aware that they will sting your dogs eyes, and long term use may contribute to kidney disease...talk this over with your vet.
Since your dog is 12 years old, please have annual bloodwork done on him to assess liver and kidney functions...bloodwork should be done on all senior dogs.
Best Wishes for you and your dog.....
Baraclude may also interact with drugs that weaken your immune system (such as cancer medicine or steroids), amphotericin B, cyclosporine, pentamidine, sirolimus, tacrolimus, and antibiotics.
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