Tacrolimus and cyclosporine
Common Questions and Answers about Tacrolimus and cyclosporine
prograf
The specialist reviewed all of the options with us - cyclosporine, pilocarpine or tacrolimus with sirolimus. She said that very rarely has she seen any dog respond to cyclosporine after not responding to tacrolimus. She also said that because our dog doesn't have a dry, goopy nose, that pilocarpine wouldn't be a first choice. She recommended a mix of tacrolimus with sirolimus. She said sirolimus is new. I have not been able to find anything about this drug on the internet.
I was initially taking Tacrolimus and then I was switched to Sirolimus. I cannot remember why my immunosuppressive was changed but Sirolimus was pretty new then and maybe my surgeon wanted to try it and see how I did. I wasn't very fond of it as I recall. It came in small packets and was an oily solution. It's been a while but I do remember that. I probably mentioned this to my surgeon and that could be the reason that he switched me back.
i would be extremely cautious about using it until more data is available especially since its purported effects on tacrolimus and cyclosporine metabolism are extreme. i am quite confident that there will be clinical trials coming down the road extremely soon.
She has been wearing the hood for 6 months to prevent her for scratching her eyes. She just turned 4 and and she is in so much pain, We finally decided to have surgery and have found out it is 2600.00 per eye. I am very worried it won't work. She just cannot enjoy her life ands she is so young. She is a shitzu-maltese mix, a wonderful little girl. I want to give her her life back. The specialist said there were no more options. The poor dog gets drops all day long and through the night.
Blood levels of tacrolimus (Prograf) can also be equally affected for the same reason as with cyclosporine. [both drugs are calcineurin inhibitors]
* omeprazole (Losec, Prilosec)
* oxycodone (Oxycodone is metabolized by the cytochrome P450 system, specifically CYP3A4, of which the bergamottin flavonoid is a strong inhibitor)
* hydrocodone (The hepatic cytochrome P450 enzyme CYP2D6 converts it into hydromorphone, a more potent opioid.
Sometimes oral corticosteroids and immunosuppressants like cyclosporine and phototherapy are used for resistant cases. Since you are having intense itching, your doctor may prescribe some sedative-antihistaminics to reduce itching. You may discuss about these treatment options with your doctor.
Besides you should take certain measures like avoiding trigger agents, keep the skin hydrated by regularly using.
My doctors want to start treatment to clear the virus. I take Prograf for the liver transplant and I know Naragenin affects the Prograf levels. My question is if during treatment I also took Naragenin and my prograf levels were closely watched and adjusted for the Naragenin effects, wouldn't I have a better chance of clearing the virus.
Thank you for the update. I am so sorry to hear this sad news.
Thats why we am trying to find out all we can as we are set for early August.
We put Tacrolimus & cyclosporine (6:00AM, 2:00pm & 7:00PM) three times a day and Teargel/Severe every hour starting at 7:00AM untill 10:00PM. So we know about not bring able to go places and travel.
I am starting to put out questions in other forums. If I find anything I will inform you.
I hope Casper can make a recovery!!
Newer two topical eczema drugs like pimecrolimus (Elidel Cream) and tacrolimus (Protopic Ointment) are reserved only for cases where corticosteroids have not been effective.
In resistant cases, oral corticosteroids and immunosuppressants like cyclosporine and phototherapy are used. Since you are having intense itching, your doctor may prescribe some sedative-antihistaminics to reduce itching. You may discuss about these treatment options with your doctor.
Can tacrolimus eye drops and Cyclosporine ointment cause cancer in dogs? My precious dog, baby and best friend was diagnosed just last week with Transitional Cell Carcinoma in his bladder. It is a rapid growing cancer. I am completely heartbroken and am wondering if there was something I could've done to prevent this. He has been on these two eye medications for about a year. His name is Duke and he is a beautiful tri-colored collie and is a little over 10 years old.
For seborrheic dermatitis, Topical antifungals and mild steroids are the usual treatment and combination of the two can be used to treat stubborn patches. Oral antifungal drugs and immunomodulators such as tacrolimus and pimecrolimus are used in very severe cases.
So you can discuss these treatment options with your dermatologist.
I hope it helps. Take care and regards.
About 6 months ago, I was finally diagnosed and started taking cyclosporine 100 mg 2x day. After a week, I could eat like a normal person—just about anything I wanted. It was great, it even allowed me to travel to Europe. The cyclosporine I was taking was a powder in a capsule, apparently this has been taken off the market and instead I took the same medication, but it was in the form of a capsule with alcohol. Unfortunately, after a short time, I was right back to before treatment.
Chronic urticaria, especially the autoimmune type, is often resistant to antihistamine treatment. They usually require immunosuppression and medications such as prednisone and cyclosporine may be given. There has been several studies already which have shown effectiveness in using cyclosporine in the treatment of chronic idiopathic urticaria, who fail to respond to conventional therapy (ref: http://www.e-ijd.org/article.asp?
One of the principal concerns with these drugs is their possible interaction with immunosuppressive drugs such as cyclosporine, tacrolimus, and sirolimus. Given that cyclosporine drug levels are increased only 4-fold when this drug is coadministered with telaprevir (Incivek, Vertex; compared to a 70-fold increase for tacrolimus), cyclosporine seems to be an attractive choice for HCV-infected transplant recipients who are planning to use a protease inhibitor.
I don't believe that OH is treating with a PI.
The PIs can increase plasma levels of tacrolimus and cyclosporine very significantly - to toxic levels. There's a lot of research regarding dosing that needs to be done before these drugs will be used in the transplant population.
My opth has diagnosed me with blepharitis, I use sterilid w/ compresses and take flaxseed oil, and I also use preservative free eyedrops for moisture. However nothing has worked to my satisfaction besides tobradex which I've used for about a year and half- my eyelid inflammation is pretty severe even with the other treatments, however w/ tobradex my symptoms are almost nonexistent.
Is there a correlation between taking less ursodiol and my through cyclosporine levels slightly decreasing? Could my lower cyclosporine levels have contributed to the lessening of my symptoms? Could taking less ursodiol have contributed to my diminishing symptoms. What would be the lest acceptable through cyclosporine level for a patient on mono -therapy four and one half years post transplant with no episodes of rejection? Thank you so very much Dr.
i wouldnt lower the tacrolimus dose further
i think this is a reasonable way of lowering the cyclosporine dose and as long as labs are being followed regularly i think that this is OK. I am not aware of rapa affecting bile flow.
Do you think it is neck pain or could it be an abdominal problem from being on pred, cyclosporine for 5 years (she has been on cyclosporine consistently for 5 years and pred on/off whenever she has a recurrence), coud it be cancer in her abdomen? I am thinking about going for a myelogram but what tests would you run else since her chemistry was pretty clean. Could it be pancreatitis even though her chemistry is clean? What are other causes for a dog crying?
For example, after each meal i now collapse with low BP when the blood rushes to the stomach to digest my food which i have had to deal with now for the past seven years and the anti rejection meds called cyclosporine have caused a lot of unpleasant 'mole like' crusty brown lesions on my torso which can be very itchy.
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