Within about six months of being on
Synthroid and without changing my diet or exercise, I began to put on weight. I gained about 15-20 pounds in six or so months. While I was mentioning this to my endocrinologist, he kept saying it wasn't the medication. I had fasting glucose, glucose tolerance, cortisol, etc., testing but all is normal. My weight gain now is about five pounds a year---doesn't sound like much but now that I'm 43, it really is.