In 19 study subjects, administration of a single 5
mg dose of amlodipine during treatment with telaprevir (750
mg every 8 hours for 7 days) increased the amlodipine peak plasma concentration (Cmax) and systemic exposure (AUC) by an average of 27% and 179%, respectively, compared to administration alone. No data are available for boceprevir; however, a similar interaction is expected.